Evidence map›Paper›PMID 40808801›Full record

ArticleComputational and structural biotechnology journal2025

gLinDA: A privacy-preserving, swarm learning toolbox for differential abundance analysis of microbiomes.

Leon Fehse, Mohammad Tajabadi, Roman Martin, Hajo Holzmann, Dominik Heider

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leon FehseUniversity of Münster, Institute of Medical Informatics, Albert-Schweitzer-Campus 1, Münster, 48149, North Rhine-Westphalia, Germany.
Mohammad TajabadiUniversity of Münster, Institute of Medical Informatics, Albert-Schweitzer-Campus 1, Münster, 48149, North Rhine-Westphalia, Germany.
Roman MartinUniversity of Münster, Institute of Medical Informatics, Albert-Schweitzer-Campus 1, Münster, 48149, North Rhine-Westphalia, Germany.
Hajo HolzmannDepartment of Mathematics and Computer Science, Philipps University of Marburg, Hans-Meerwein-Str. 6, Marburg, 35032, Hesse, Germany.
Dominik HeiderUniversity of Münster, Institute of Medical Informatics, Albert-Schweitzer-Campus 1, Münster, 48149, North Rhine-Westphalia, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Count data, such as gene expression and microbiome composition, play a significant role in various diseases, including cancer, obesity, inflammatory bowel disease, and mental health disorders. For instance, understanding the differences in microbial abundance between patients is essential for uncovering the microbiome's impact on these conditions. Differential abundance analysis (DAA) can detect significant changes between groups of patients. However, since individuals have unique microbial fingerprints that could potentially be identifiable, microbiome data must be treated as sensitive patient data, which poses problems for collaborative studies in the medical field. In this work, we introduce gLinDA, a global differential abundance analysis tool that employs a privacy-preserving swarm learning approach for the analysis of distributed datasets. gLinDA maintains predictive performance while safeguarding patient sensitive data.

Indexed as

Differential abundance analysisMicrobiomeSwarm learning

Identifiers

PMID40808801
PMCPMC12345345

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.