ArticleFrontiers in pharmacology2025
Anlotinib combined with penpulimab in the treatment of advanced adult thoracic spinal osteosarcoma: a case report.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Spinal osteosarcoma is a rare and prognostically poor subtype of osteosarcoma, with limited efficacy from traditional chemoradiotherapy. The potential of targeted therapy combined with immunotherapy requires further exploration. Case Summary: A 53-year-old female with stage IV thoracic spinal osteosarcoma initially received intensity-modulated radiotherapy (total dose of 45 Gy in 15 fractions) and AP chemotherapy (doxorubicin 60 mg/m Lessons: This case demonstrates that sequential molecular targeted therapy and immunotherapy following chemoradiation can yield remarkable clinical outcomes, offering a novel therapeutic option for advanced spinal osteosarcoma. However, interindividual variations in treatment response underscore the need for future research to identify predictive biomarkers for patient stratification.
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