Evidence map›Paper›PMID 40808634›Full record

ArticleMacromolecular rapid communications2025

Lyotropy as a Design Consideration for Ultra-Small Protein Nanoparticles via Electrohydrodynamic Jetting.

Muhammad Haseeb Iqbal, Julio Zelaya, Quy Ong, Francesco Stellacci, Joerg Lahann

Abstract read
In one paragraph

Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad Haseeb IqbalInstitute of Functional Interfaces, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Julio ZelayaBiointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA.
Quy OngInstitute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Francesco StellacciInstitute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Joerg LahannInstitute of Functional Interfaces, Karlsruhe Institute of Technology, Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-3334-2053

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-based nanoparticles offer tailored bioactivity and biodegradability that are distinct from their synthetic polymeric counterparts. Precise engineering of physical properties, especially size, of nanoparticles using electrohydrodynamic (EHD) jetting is a crucial factor that defines the fate of delivery systems in nanomedicine. Herein, we establish a systematic understanding that leads to the preparation of human serum albumin (HSA) nanoparticles with sizes as small as 50 nm. Interestingly, the addition of salt at very low concentrations, around 1-5 mm, combined with EHD process parameters, can result in narrow distributions of particle sizes that are consistently below 100 nm. At a given concentration, i.e., 2 mm, anions modulate the particle diameters that follow the Hofmeister Series as SO

Indexed as

NanoparticlesSerum Albumin, HumanDrug Delivery SystemsHumansParticle SizeSerum Albumin, Humanelectrosprayinghofmeister effectnanoparticle sizeproteinssalts

Identifiers

PMID40808634
PMCPMC12687699

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.