Evidence map›Paper›PMID 40808633›Full record

ArticleMacromolecular bioscience2025

A Triple-Layered Composite Scaffold of Silk Fibroin and Decellularized Amniotic Membrane for Bladder Tissue Engineering.

Melina Mamdoohi, Mehdi Shafieian, Zahra Hassannejad

Abstract read
In one paragraph

Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Melina MamdoohiDepartment of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Mehdi ShafieianDepartment of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.ORCID 0000-0001-8533-0241
Zahra HassannejadPediatric Urology and Regenerative Medicine Research Center, Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Funding

Tehran University of Medical Sciences and Health Services 46007-145-2-99
6 · The paper itself

Abstract

Augmentation cystoplasty has different side effects in urinary bladder reconstruction. Accordingly, it is necessary to develop substitutes using natural and synthetic biomaterials to address current problems. This study evaluates the potential of a triple-layered composite scaffold for bladder regeneration. The triple-layered scaffold consists of a silk fibroin (SF) film blended with polyethylene oxide (PEO), a decellularized human amniotic membrane (DHAM), and a lyophilized SF sponge, which is seeded with adipose tissue-derived stem cells (ADSCs) encapsulated in collagen hydrogel. The mechanical properties of the triple-layered scaffolds closely resemble those of human bladder tissue. The cell survival, proliferation, and viability of the different layers of the scaffold are assessed. The results show that DHAM and silk sponge at a concentration of 4% wt v

Indexed as

AmnionFibroinsTissue EngineeringTissue ScaffoldsUrinary BladderAdipose TissueAnimalsBiocompatible MaterialsBombyxCell ProliferationCell SurvivalCollagenHumansHydrogelsMicroscopy, Electron, ScanningPlastic Surgery ProceduresBiocompatible MaterialsCollagenFibroinsHydrogelsadipose tissue‐derived stem cellsamniotic membranebladder regenerationSFtissue engineering

Identifiers

PMID40808633
PMCPMC12617677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.