Evidence map›Paper›PMID 40808547›Full record

ArticlemAbs2025

Pioneer: a synthetic human antibody phage display library for rapid therapeutic lead generation.

Mateusz Putyrski, Christian Hentrich, Manuel Cavada, Melissa Wich, Sarah-Jane Kellmann, Sarah Hanselka, Michaela Eick-Werner, Hanh Hanuschka, Waldemar Preis, Christina Werkmeister and 3 more

Abstract read
In one paragraph

Article in mAbs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mateusz PutyrskiBio-Rad AbD Serotec GmbH, Neuried, Germany.
Christian HentrichBio-Rad AbD Serotec GmbH, Neuried, Germany.
Manuel CavadaBio-Rad AbD Serotec GmbH, Neuried, Germany.
Melissa WichBio-Rad AbD Serotec GmbH, Neuried, Germany.
Sarah-Jane KellmannBio-Rad AbD Serotec GmbH, Neuried, Germany.ORCID 0000-0001-7259-4264
Sarah HanselkaBio-Rad AbD Serotec GmbH, Neuried, Germany.
Michaela Eick-WernerBio-Rad AbD Serotec GmbH, Neuried, Germany.
Hanh HanuschkaBio-Rad AbD Serotec GmbH, Neuried, Germany.
Waldemar PreisBio-Rad AbD Serotec GmbH, Neuried, Germany.
Christina WerkmeisterBio-Rad AbD Serotec GmbH, Neuried, Germany.
Martina KleeBio-Rad AbD Serotec GmbH, Neuried, Germany.
Achim KnappikBio-Rad AbD Serotec GmbH, Neuried, Germany.ORCID 0000-0002-2693-6750
Francisco YleraBio-Rad AbD Serotec GmbH, Neuried, Germany.ORCID 0000-0002-3230-4151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibody phage display, a biotechnological method for selecting fully human antibodies from diverse libraries, is firmly established in antibody drug discovery due to its speed and flexibility. In this study, we introduce Pioneer, one of the largest synthetic human antibody libraries developed to date, with approximately 2.2 × 10

Indexed as

Cell Surface Display TechniquesDrug DiscoveryPeptide LibraryHumansReceptors, CXCR4Peptide LibraryReceptors, CXCR4Antibody developabilityC5aRCXCR4fab antibody libraryGPCRhigh-affinity antibodiesIL-6RAPhage displaySpyCatcherSpyDisplaySpyTagTIGIT

Identifiers

PMID40808547
PMCPMC12355719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.