Evidence map›Paper›PMID 40808486›Full record

Observational studyObesity (Silver Spring, Md.)2025

PFAS Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen-LABS Study.

Brittney O Baumert, Elizabeth Costello, Zhenjiang Li, Justin R Ryder, Thomas Inge, Todd Jenkins, Stephanie Sisley, Stavra A Xanthakos, Douglas I Walker, Nikos Stratakis and 11 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00474318 (Teen-Longitudinal Assessment of Bariatric Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00474318 completednot on this map

Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research Project

TypeobservationalSponsorAnn & Robert H Lurie Children's Hospital of ChicagoRan2007 to 2024Enrolled250ConditionsObesity
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Brittney O BaumertDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-1220-8557
Elizabeth CostelloDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-5094-9017
Zhenjiang LiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-4806-6231
Justin R RyderDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Thomas IngeDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-7782-1112
Todd JenkinsDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Stephanie SisleyDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Stavra A XanthakosDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Atlanta, Georgia, USA.
Nikos StratakisBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain.
Damaskini ValviDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Scott M BartellDepartment of Environmental and Occupational Health, University of California, Irvine, Irvine, California, USA.
Angela L SlittCollege of Pharmacy, The University of Rhode Island, Kingston, Rhode Island, USA.
Rohit KohliDivision of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, California, USA.
Sarah RockDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Michele A La MerrillDepartment of Environmental Toxicology, University of California, Davis, Davis, California, USA.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Max T AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
David V ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWALP42ES027706 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI Rainer Lohmann · 2017 to 2026
$18.9M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research ProjectUM1DK072493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI INGE, THOMAS HARRIS · 2011 to 2020
$10.5M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2012 to 2014
$9.9M
Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewalUM1DK095710 · NIDDK · UNIVERSITY OF CINCINNATI · PI JENKINS, TODD M, XIE, CHANGCHUN · 2011 to 2020
$9.4M
Adolescent Bariatrics: Assessing Health Benefits & RisksU01DK072493 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI INGE, THOMAS HARRIS · 2006 to 2010
$8.7M
Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP)P42ES036506 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAIA LIDA CHATZI · 2025 to 2026
$8.2M
Untargeted Analysis ResourceU2CES030859 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2019 to 2025
$8.2M
Training Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6M
NCATS NIH HHS 8UL1TR000077NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114NCI NIH HHS P01 CA196569NHGRI NIH HHS U01 HG013288NIDDK NIH HHS R01 DK128117NIDDK NIH HHS U01 DK072493NIDDK NIH HHS UM1 DK072493NIDDK NIH HHS UM1 DK095710NIEHS NIH HHS 1P42ES036506NIEHS NIH HHS P2C ES033433NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30ES007048NIEHS NIH HHS P30 ES023515NIEHS NIH HHS P30ES023515NIEHS NIH HHS P42 ES027706NIEHS NIH HHS P42 ES036506NIEHS NIH HHS R01 ES029944NIEHS NIH HHS R01ES029944NIEHS NIH HHS R01 ES030364NIEHS NIH HHS R01ES030364NIEHS NIH HHS R01 ES030691NIEHS NIH HHS R01ES030691NIEHS NIH HHS R01 ES032831NIEHS NIH HHS R01ES032831NIEHS NIH HHS R01 ES033688NIEHS NIH HHS R01ES033688NIEHS NIH HHS R01 ES037367NIEHS NIH HHS R21 ES029681NIEHS NIH HHS R21 ES035148NIEHS NIH HHS R21ES035148NIEHS NIH HHS T32 ES013678NIEHS NIH HHS T32-ES013678NIEHS NIH HHS U01HG013288NIEHS NIH HHS U2C ES030859NIEHS NIH HHS U2CES030859NIH HHS U01DK072493NIH HHS UM1 DK072493NIH HHS UM1 DK095710
6 · The paper itself

Abstract

objectiveWeight regain following bariatric surgery remains a clinical challenge, with limited understanding of contributing environmental factors. Per- and polyfluoroalkyl substances (PFAS), persistent chemicals linked to metabolic dysfunction, may influence long-term weight trajectories. This study aimed to evaluate associations between PFAS exposure and changes in BMI, percent weight loss, and waist circumference among adolescents after bariatric surgery.

methodsWe included 186 adolescents (mean age: 17.1 years; 76.3% female; 72.0% White) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort who underwent surgery between 2007 and 2012. Anthropometric measurements were collected at baseline and 6, 12, 36, and 60 months post surgery. Presurgical plasma concentrations of seven PFAS were measured using liquid chromatography-tandem mass spectrometry. Associations were estimated using linear mixed-effects models and quantile g-computation.

resultsHigher concentrations of PFOS, PFHxS, and PFHpS were associated with greater BMI regain, reduced percent weight loss, and increased waist circumference from 1 to 5 years post surgery. At PFOS concentrations of 1.45 to 2.94 log

conclusionsPFAS exposure was associated with weight regain after bariatric surgery in adolescents, potentially undermining long-term metabolic benefits.

trial registrationClinicalTrials.gov identifier NCT00474318.

Indexed as

Bariatric SurgeryEnvironmental ExposureFluorocarbonsPediatric ObesityWeight GainAdolescentAlkanesulfonic AcidsBody Mass IndexFemaleHumansLongitudinal StudiesMalePostoperative PeriodSulfonic AcidsWaist CircumferenceWeight LossAlkanesulfonic AcidsFluorocarbonsperflexaneperfluorohexanesulfonic acidperfluorooctane sulfonic acidSulfonic Acidsadolescentsbariatric surgeryBMImetabolic healthPFASweight regain

Identifiers

PMID40808486
PMCPMC12424438

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.