ArticleSmall methods2026
The Effect of Mechanical Loading on Sprouting Angiogenesis from Engineered Macro-vessel Model.
Article in Small methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Phased affinity-controlled delivery of vascular endothelial growth factor, fibroblast growth factor-2, and platelet derived growth factor enhances in vitro angiogenesis.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- 4D force patterning enables spatial control of angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The influence of mechanical signals on sprouting angiogenesis has been of interest in the field of tissue engineering and biomechanics. Here, a unique experimental methodology is developed to apply mechanical loading on an engineered macro-vessel model to study the influence on angiogenic sprouting. The polydimethylsiloxane (PDMS) stretchable device contains an engineered macro-vessel embedded within a collagen matrix. The model is loaded either parallel or perpendicular to the macro-vessel (longitudinal or lateral, respectively). A finite element analysis is performed to characterize the strain maps of the PDMS-collagen setup. The results indicate high uniform strain around the macro-vessel perimeter under longitudinal loading, while lateral loading results in low strain in the horizontal direction and high strain along the vertical direction. Experimental results for lateral loading show increased sprouting events and capillary orientation in the stretch direction following the organization of matrix fibers, while longitudinal loading results in sprouting inhibition. These findings allow prediction of angiogenic sprouting under specified mechanical loading profiles and may serve as a tool to rationally design and control vascular network architecture by physical means. Finally, the presented approach can serve as a platform for studying cell behavior under mechanical loading for any physiological tubular duct or vessel model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.