ArticleNeural regeneration research2026
Magnesium and nerve injury: Mechanisms and applications.
Article in Neural regeneration research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Mechanism-Driven Design of Metal-Phenolic Networks: From Precision Assembly to Multidimensional Synergistic Therapy for Brain Diseases.Pharmaceutics · 2026Review
- Real-World Before-After Study ofNutrients · 2026Article
- Spatiotemporal Co-Delivery of Hydrogen and Magnesium via Microneedle Patches for Neuroinflammation Modulation After Spinal Cord Injury: A Multi-Modal In Vivo Study.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium is a vital mineral that plays an important role in recovery from nerve injury recovery by inhibiting excitotoxicity, suppressing inflammatory effects, reducing oxidative stress, and protecting mitochondria. The role of magnesium ions in the field of nerve injury repair has garnered substantial attention. This paper aims to review the mechanisms of action and potential applications of magnesium in nerve injury repair. Magnesium ions, as key neuroregulatory factors, substantially alleviate secondary damage after nerve injury by inhibiting N-methyl-D-aspartate receptors, regulating calcium ion balance, providing anti-inflammatory and antioxidant effects, and protecting mitochondrial function. Magnesium ions have been shown to reduce neuronal death caused by excitotoxicity, inhibit the release of inflammatory factors, and improve mitochondrial function. Additionally, magnesium materials, such as metallic magnesium, magnesium alloys, surface-modified magnesium materials, and magnesium-based metallic glass, exhibit unique advantages in nerve repair. For example, magnesium materials can control the release of magnesium ions, thereby promoting axonal regeneration and providing mechanism support. However, the rapid corrosion of magnesium materials and the limited amount of research on these materials hinder their widespread application. Existing small-sample clinical studies have indicated that magnesium formulations show some efficacy in conditions such as migraines, Alzheimer's disease, and traumatic brain injury, offering a new perspective for the application of magnesium in nerve injury rehabilitation. Magnesium ions and their derived materials collectively hold great promise for applications in nerve injury repair. Future efforts should focus on in-depth research on the mechanisms of action of magnesium ions and the development of magnesium-based biomaterials with enhanced performance. Additionally, large-scale clinical trials should be conducted to validate their safety and efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.