Evidence map›Paper›PMID 40808340›Full record

ArticleMolecular medicine reports2025

ER‑α36 knockdown is associated with lysosomal dysfunction and proliferation inhibition in liver cancer cells.

Huanhuan He, Xuan Wang, Zhixuan Wei, An Wang, Xiangyue Fang, Hanbo He, Zhuorui Wu, Xiji Shu, Binlian Sun, Qiongxia Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Huanhuan He *Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Xuan Wang *Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Zhixuan Wei *Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
An WangDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Xiangyue FangDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Hanbo HeDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Zhuorui WuDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Xiji ShuDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Binlian SunCancer Institute, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Qiongxia ChenDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Xuan HuangDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Hongyan ZhouDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Yuchen LiuCancer Institute, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Zhengqi FuDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogen receptor (ER)‑α36 and autophagy have each independently been reported to promote the proliferation of liver cancer cells; however, the association between them has not been explored. Therefore, the present study aimed to investigate the role and the underlying mechanism of ER‑α36 in the regulation of autophagy in liver cancer cells. The proliferation of liver cancer cell variants was examined by colony formation assay. A xenograft tumor model in nude mice was used to examine the role of ER‑α36 in malignant proliferation of liver cancer cells

Indexed as

Estrogen Receptor alphaLiver NeoplasmsLysosomesAnimalsAutophagyCell Line, TumorCell ProliferationGene Knockdown TechniquesHep G2 CellsHumansMiceMice, NudeProto-Oncogene Proteins c-aktEstrogen Receptor alphaProto-Oncogene Proteins c-aktAKTestrogen receptor‑α36liver cancer cellslysosomal degradationlysosomal membrane permeabilization

Identifiers

PMID40808340
PMCPMC12365738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.