ArticleJournal of animal science2025
Study on the mechanism of induced ovulation in rabbits.
Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Rabbits are induced ovulators, meaning they ovulate in response to mating or other physical and chemical stimuli. However, to date, research on candidate genes associated with ovulation in female rabbits remains limited, and the specific molecular mechanisms underlying ovulation in does are still unclear. Thirty healthy Hycole female rabbits were assigned to five groups: Group A (slaughtered immediately post-estrus as a baseline control), Group B (blank control), Group C (vaginal saline infusion), Group D (artificial insemination), and Group E (natural mating). Rabbits in Groups B through E were slaughtered 10 h post-treatment. Ovulatory follicles were observed exclusively in Groups D and E. Serum hormone analysis revealed significantly elevated levels of progesterone and luteinizing hormone in Group E compared to the other groups. Transcriptome analysis revealed that, compared to Group A, the ovarian tissue from Group C exhibited 686 differentially expressed genes (DEGs), while Groups D and E exhibited 645 and 637 DEGs, respectively. Functional enrichment analysis and protein-protein interaction (PPI) network construction identified several candidate genes, including RBP4, INHA, AKR1B10, S100A9, AKR1B1, INHBA, CYP19A1, and BMP2. These genes were primarily enriched in cytokine-cytokine receptor interaction, Hippo signaling pathway, and Pentose and glucuronate interconversions. These genes and their associated pathways collectively contribute to ovulation in rabbits, providing novel experimental data to further elucidate the mechanisms of stimulated ovulation. This research contributes to enhancing reproductive efficiency and advancing molecular breeding studies in rabbits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.