ArticleMagnetic resonance in medicine2026
Absolute quantification of cerebral metabolites using two-dimensional proton MR spectroscopic imaging with quantitative MRI-based water reference.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Absolute quantification of cerebral metabolites using two-dimensional proton MR spectroscopic imaging with quantitative MRI-based water reference.Magnetic resonance in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeMetabolite concentrations are valuable biomarkers in brain tumors (BTs). However, absolute quantification of metabolites using MR spectroscopy requires a correction of water relaxation using time-consuming quantitative MRI (qMRI) sequences in addition to a lengthy two-dimensional spectroscopic water-reference acquisition. The goal of this work was to develop and validate a fast quantification method where a two-dimensional spectroscopic water reference is obtained using qMRI and a single-voxel stimulated-echo acquisition mode (STEAM) sequence.
methodsThe semi-adiabatic localization by adiabatic selective refocusing (sLASER) sequence was used for MR spectroscopy imaging (MRSI) acquisition. A single-voxel unsuppressed water signal was acquired using a STEAM sequence. A qMRI protocol was also acquired, and the H
resultsIn healthy subjects, white-matter metabolite concentrations obtained using water relaxation using literature values (reference method) significantly differed from those using individual-specific corrections (reference method with qMRI and proposed method). Bland-Altman analyses revealed a very low bias and standard deviation of the differences between the reference method with qMRI and the proposed method (bias < 0.5% and standard deviation < 10%). The BT regions showed an approximate 35% underestimation of metabolite concentrations using the reference method.
conclusionFor metabolite quantification, accurate water referencing with individual-specific corrections for water relaxation times was obtained in 8 min using the proposed method.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.