Evidence map›Paper›PMID 40808260›Full record

ArticleCancer science2025

SOX10 Regulates Melanoma Metastasis Through the IRF1-ITGA3/EphA2-FAK Pathway.

Ryuya Kaminaka, Nana Takahashi, Mayu Nishizawa, Soichiro Sasaki, Yuichiro Sugihara, Minoru Matsumoto, Ryoma Taniguchi, Yue Zhou, Yoshihiro Hayakawa, Hiroaki Sakurai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryuya KaminakaDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Nana TakahashiDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Mayu NishizawaDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Soichiro SasakiDivision of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan.ORCID https://orcid.org/0000-0001-9092-7181
Yuichiro SugiharaDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Minoru MatsumotoDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Ryoma TaniguchiDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Yue ZhouDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Yoshihiro HayakawaDivision of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan.ORCID https://orcid.org/0000-0002-7921-1171
Hiroaki SakuraiDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Satoru YokoyamaDepartment of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.ORCID https://orcid.org/0000-0001-8336-486X

Funding

Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research 23K24026Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research 24K10355
6 · The paper itself

Abstract

Melanoma heterogeneity contributes to increased metastatic potential. Although a subpopulation characterized by MITF

Indexed as

Focal Adhesion Kinase 1Interferon Regulatory Factor-1MelanomaReceptor, EphA2SOXE Transcription FactorsAnimalsCell AdhesionCell Line, TumorCell MovementEphrin-A2Gene Expression Regulation, NeoplasticHumansMiceNeoplasm MetastasisPhosphorylationSignal TransductionEPHA2 protein, humanEphrin-A2Focal Adhesion Kinase 1Interferon Regulatory Factor-1PTK2 protein, humanReceptor, EphA2SOX10 protein, humanSOXE Transcription FactorsEphA2IRF1ITGA3melanomametastasisSOX10

Identifiers

PMID40808260
PMCPMC12580875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.