Evidence map›Paper›PMID 40808216›Full record

Trial reportThe clinical respiratory journal2025

The Early Effects of Esketamine on the Tumor Metastatic Microenvironment in Postoperative Lung Cancer Patients.

Yong Wang, Weijing Li, Li Jia, Junmei Shen, Chao Li, Huiqun Jia

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The clinical respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yong WangDepartment of Anesthesiology, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Weijing LiDepartment of Anesthesiology, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Li JiaDepartment of Anesthesiology, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Junmei ShenDepartment of Anesthesiology, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Chao LiDepartment of Anesthesiology, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Huiqun JiaDepartment of Anesthesiology, The Forth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.ORCID https://orcid.org/0009-0006-3304-1310

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the early effect of esketamine on the tumor metastatic microenvironment in patients with lung cancer.

methodsSixteen adults aged 45-80 years with the American Society of Anesthesiologists (ASA) 1 to 3 were randomly divided into the experimental group (group E) and the control group (group C). Group E received esketamine at 1 mg/kg during anesthesia induction and a continuous infusion of 0.5 mg/kg/h during the surgery. Group C was given the same amount of normal saline infusion. Patient-controlled intravenous analgesia (PCIA) in group E was administered using dexmedetomidine (0.5 mg/kg) + esketamine (50 mg) + dexamethasone (5 mg). PCIA in group C was the same dose of dexmedetomidine and dexamethasone. Data were recorded at 14 points from admission to the third day after surgery (T

resultsCompared with T

conclusionPerioperative application of esketamine in patients with lung cancer provided significant sedative and analgesic effects and affected cytokines in the tumor microenvironment.

Indexed as

KetamineLung NeoplasmsTumor MicroenvironmentAgedAged, 80 and overAnalgesia, Patient-ControlledDexamethasoneDexmedetomidineFemaleHumansMaleMiddle AgedPostoperative PainDexamethasoneDexmedetomidineEsketamineKetamineesketaminelung cancerMMP‐9TNF‐αtumor microenvironment metastasisVEGF‐C

Identifiers

PMID40808216
PMCPMC12350540

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.