Controllable Structure and Fluorescence Enhancement of ACQ Dye Nanoparticles Based on the FNP Process.

Yue Wu, Yutao Zhang, Zhiqian Guo, Yisheng Xu

Abstract read

In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Yue WuCenter of Photosensitive Chemicals Engineering, State Key Laboratory of Green Chemical Engineering and Industrial Catalysis, State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.

Yutao ZhangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.

Zhiqian GuoKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.

Yisheng XuCenter of Photosensitive Chemicals Engineering, State Key Laboratory of Green Chemical Engineering and Industrial Catalysis, State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.

Funding

National Key Research and Development Program 2021YFE0100400National Key Research and Development Program 2023YFA1802000National Natural Science Foundation of China 22225805National Natural Science Foundation of China 22378126National Natural Science Foundation of China 32121005National Natural Science Foundation of China 32394001Science and Technology Innovation Plan of Shanghai Science and Technology Commission 22501100500

6 · The paper itself

Abstract

Fluorescent dyes, such as cyanine dyes, are widely used in fluorescence-imaging-guided tumor therapy due to their high absorbance and fluorescence quantum yield. However, challenges persist in optimizing the performance of fluorescent nanoparticles, particularly due to the aggregation-caused quenching (ACQ) effect of cyanine dyes. Here, a novel counterion construction strategy is introduced using cyanine dye as a model ACQ dye. Through dynamic-controlled flash nanoprecipitation, fluorescent nanoparticles (CyINPs) with tunable structures are developed, investigating the effects of various factors, including counterions, block copolymers, and dye concentrations, on CyINPs' stability and fluorescence enhancement. The optimized CyINPs with good water solubility show a 21-fold increase in fluorescence intensity and a 3.5-fold increase in encapsulation efficiency compared to CyINPs prepared by a thermodynamic-driven method. Under the efforts of polymers and counterions, dyes are separated, which reduces the impact of the ACQ effect and results in stronger fluorescence intensity, providing insights into improving nanoparticle biocompatibility and energy utilization efficiency.

Indexed as

ACQ effectflash nanoprecipitationfluorescence enhancementfluorescence nanoparticles

Identifiers

PMID40808200

DOI10.3390/polym17152152

PMCPMC12349522

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.