Evidence map›Paper›PMID 40807480›Full record

ArticleMolecules (Basel, Switzerland)2025

GelMA Core-Shell Microgel Preparation Based on a Droplet Microfluidic Device for Three-Dimensional Tumor Ball Culture and Its Drug Testing.

Xindong Yang, Yi Xu, Dongchen Zhu, Xianqiang Mi

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xindong YangSchool of Microelectronics, Shanghai University, Shanghai 200444, China.
Yi XuShanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Dongchen ZhuShanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.ORCID 0000-0001-5124-4409
Xianqiang MiSchool of Microelectronics, Shanghai University, Shanghai 200444, China.

Funding

CAS-NSTDA Joint Research Project, China-Thailand (2024) 101GJHZ2024017M1Chinese Academy of Science KFJ-STS-QYZD-2021-08-002National Key Research and Development Program of China 2022YFC3500115National Key Research and Development Program of China 2022YFC3502002National Key Research and Development Program of China 2022YFC3502005Program of Shanghai Academic/Technology Research Leader 20XD1404600Shanghai Municipal Science and Technology Commission 20511107600
6 · The paper itself

Abstract

Gelatin methacrylate (GelMA) microgels serve as promising bioscaffolds for tissue engineering and drug screening. However, conventional solid GelMA microgels often exhibit limited mass transfer efficiency and provide insufficient protection for embedded cells. In this study, we developed a droplet-based microfluidic platform to fabricate core-shell structured GelMA microgels. This system enabled precise control over microgel size and core-to-shell ratio by modulating flow rates. Encapsulation of A549 cells within these core-shell microgels preserved cellular viability and facilitated the formation of three-dimensional tumor spheroids. These outcomes confirmed both the protective function of the core-shell architecture during encapsulation and the overall biocompatibility of the microgels. The developed GelMA core-shell microgel system presents considerable applicability in research domains such as organoid modeling and high-throughput pharmacological screening.

Indexed as

GelatinLab-On-A-Chip DevicesMethacrylatesMicrogelsA549 CellsAntineoplastic AgentsCell SurvivalDrug Screening Assays, AntitumorHumansMicrofluidicsSpheroids, CellularAntineoplastic AgentsGelatinMethacrylatesMicrogels3D cell culturecore–shell microgeldroplet microfluidicdrug testingGelMA

Identifiers

PMID40807480
PMCPMC12348063

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.