Structure-Activity Relationships in Alkoxylated Resorcinarenes: Synthesis, Structural Features, and Bacterial Biofilm-Modulating Properties.

Mariusz Urbaniak, Łukasz Lechowicz, Barbara Gawdzik, Maciej Hodorowicz, Ewelina Wielgus

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In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Mariusz UrbaniakInstitute of Chemistry, Faculty of Natural Sciences, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.

Łukasz LechowiczInstitute of Biology, Faculty of Natural Sciences, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.ORCID 0000-0002-7180-3324

Barbara GawdzikInstitute of Chemistry, Faculty of Natural Sciences, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.

Maciej HodorowiczFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.

Ewelina WielgusCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.ORCID 0000-0002-5325-6072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a series of novel alkoxylated resorcinarenes were synthesized using secondary and tertiary alcohols under mild catalytic conditions involving iminodiacetic acid. Structural characterization, including single-crystal X-ray diffraction, confirmed the successful incorporation of branched alkyl chains and highlighted the influence of substitution patterns on molecular packing. Notably, detailed mass spectrometric analysis revealed that, under specific conditions, the reaction pathway may shift toward the formation of defined oligomeric species with supramolecular characteristics-an observation that adds a new dimension to the synthetic potential of this system. To complement the chemical analysis, selected derivatives were evaluated for biological activity, focusing on bacterial growth and biofilm formation. Using four clinically relevant strains (

Indexed as

Anti-Bacterial AgentsBiofilmsCalixarenesPhenylalanineBacillus subtilisCrystallography, X-RayEscherichia coliMicrobial Sensitivity TestsMolecular StructurePseudomonas aeruginosaStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsCalixarenesPhenylalanineresorcinarenealkoxylationbacterial stress responsebiofilm formationresorcinarene

Identifiers

PMID40807479

DOI10.3390/molecules30153304

PMCPMC12348843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.