Lipase-Catalyzed Cyclization of β-Ketothioamides with β-Nitrostyrene for the Synthesis of Tetrasubstituted Dihydrothiophenes.

Yihang Dai, Yuming Piao, Wenbo Kan, Lei Wang, Yazhuo Li

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Porcine pancreas lipase: a versatile biocatalyst.Biotechnology letters · 2026
Review

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5 · Who and what money

Authors and funding

5 authors.

Yihang DaiKey Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130023, China.

Yuming PiaoKey Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130023, China.

Wenbo KanKey Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130023, China.

Lei WangKey Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130023, China.

Yazhuo LiCollege of Food Science and Engineering, Jilin University, Changchun 130062, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrasubstituted dihydrothiophenes represent a class of heterocyclic compounds with significant potential in various fields, particularly in medicinal chemistry and materials science. In this work, we have developed an eco-friendly and efficient method for synthesizing such compounds, using porcine pancreatic lipase (PPL) as a biocatalyst to promote the cyclization reaction between β-ketothioamides and β-nitrostyrenes. Through this approach, sixteen tetrasubstituted dihydrothiophenes were successfully synthesized, and all of them achieved high yields, ranging from 80% to 96%. This research not only expands the application scope of lipase in organic synthesis, demonstrating its versatility beyond traditional hydrolytic reactions, but also provides a new environmentally friendly pathway for the production of tetrasubstituted dihydrothiophenes, which is of great significance for advancing related fields of chemical synthesis.

Indexed as

broad substrate scopeenvironmentally friendly pathwayhigh yieldone-pot synthesisporcine pancreatic lipasesimple post-processingtetrasubstituted dihydrothiophenes

Identifiers

PMID40807375

DOI10.3390/molecules30153202

PMCPMC12348498

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