Evidence map›Paper›PMID 40807350›Full record

ArticleMolecules (Basel, Switzerland)2025

Adolat Manakbayeva, Andrey Bogoyavlenskiy, Timur Kerimov, Igor Yershov, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Vyacheslav Dushenkov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adolat ManakbayevaResearch and Production Center for Microbiology and Virology, Almaty 050010, Kazakhstan.ORCID 0000-0003-3256-3484
Andrey BogoyavlenskiyResearch and Production Center for Microbiology and Virology, Almaty 050010, Kazakhstan.
Timur KerimovResearch and Production Center for Microbiology and Virology, Almaty 050010, Kazakhstan.ORCID 0009-0005-6691-4969
Igor YershovResearch and Production Center for Microbiology and Virology, Almaty 050010, Kazakhstan.ORCID 0009-0007-9914-9364
Pavel AlexyukResearch and Production Center for Microbiology and Virology, Almaty 050010, Kazakhstan.ORCID 0000-0003-3638-3341
Madina AlexyukResearch and Production Center for Microbiology and Virology, Almaty 050010, Kazakhstan.
Vladimir BerezinResearch and Production Center for Microbiology and Virology, Almaty 050010, Kazakhstan.ORCID 0000-0003-2648-8975
Vyacheslav DushenkovDepartment of Natural Sciences, Hostos Community College CUNY, Bronx, NY 10451, USA.ORCID 0000-0001-5176-7461

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan AP19678025
6 · The paper itself

Abstract

Organic acids, as natural metabolites, play crucial roles in human metabolism and health. Tumor Necrosis Factor (TNF), a pivotal mediator in immune regulation and inflammation, is a key therapeutic target. We evaluated ten organic acids as TNF modulators using in silico molecular docking, followed by detailed ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling and molecular dynamics (MD) simulations for three lead candidates:

Indexed as

CarotenoidsGallic AcidTumor Necrosis Factor-alphaAnimalsGene Expression ProfilingGene Expression RegulationHumansMiceMolecular Docking SimulationMolecular Dynamics SimulationVitamin ACarotenoidsGallic Acidtrans-sodium crocetinateTumor Necrosis Factor-alphaVitamin AADMETgene expressionimmunomodulatormolecular dockingTNF

Identifiers

PMID40807350
PMCPMC12348193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.