Evidence map›Paper›PMID 40807329›Full record

ArticleMolecules (Basel, Switzerland)2025

Classical Paal-Knorr Cyclization for Synthesis of Pyrrole-Based Aryl Hydrazones and In Vitro/In Vivo Evaluation on Pharmacological Models of Parkinson's Disease.

Maya Georgieva, Martin Sharkov, Emilio Mateev, Diana Tzankova, Georgi Popov, Vasil Manov, Alexander Zlatkov, Rumyana Simeonova, Magdalena Kondeva-Burdina

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Transmetalation in Cancer Pharmacology.International journal of molecular sciences · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maya GeorgievaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0002-4752-5002
Martin SharkovDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.
Emilio MateevDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0002-5885-7213
Diana TzankovaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0002-1708-1287
Georgi PopovDepartment of Internal Non-Communicable Diseases, Pathology and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, 10 St. Kliment Ohridski Blvd., 1797 Sofia, Bulgaria.
Vasil ManovDepartment of Internal Non-Communicable Diseases, Pathology and Pharmacology, Faculty of Veterinary Medicine, University of Forestry, 10 St. Kliment Ohridski Blvd., 1797 Sofia, Bulgaria.ORCID 0000-0001-9306-3665
Alexander ZlatkovDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0002-1695-8454
Rumyana SimeonovaDepartment of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0003-4860-9053
Magdalena Kondeva-BurdinaDepartment of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0001-6776-0870

Funding

European Union-NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria BG-RRP-2.004-0004-C01.
6 · The paper itself

Abstract

Some studies performed in our laboratory on pyrrole and its derivatives pointed towards the enrichment of the evaluations of these promising chemical structures for the potential treatment of neurodegenerative conditions in general and Parkinson's disease in particular. A classical Paal-Knorr cyclization approach is applied to synthesize the basic hydrazine used for the formation of the designed series of hydrazones (

Indexed as

HydrazonesNeuroprotective AgentsParkinson DiseasePyrrolesAnimalsBrainCyclizationDisease Models, AnimalLipid PeroxidationMaleMitochondriaMonoamine Oxidase InhibitorsOxidative StressRatsRats, WistarSynaptosomesHydrazonesMonoamine Oxidase InhibitorsNeuroprotective AgentsPyrroleshydrazonein vivoParkinson’spyrrolesynthesis

Identifiers

PMID40807329
PMCPMC12348509

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.