Versatile High-Performance Liquid Chromatography and Ultraviolet Detection-Based Method for the Determination of Thioproline in Pharmaceutical and Cosmetic Products.

Marta Gaweł, Martyna Płodzik, Rafał Głowacki, Justyna Piechocka

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marta GawełDepartment of Environmental Chemistry, Faculty of Chemistry, University of Lodz, 163/165 Pomorska Str., 90-236 Łódź, Poland.

Martyna PłodzikDepartment of Environmental Chemistry, Faculty of Chemistry, University of Lodz, 163/165 Pomorska Str., 90-236 Łódź, Poland.

Rafał GłowackiDepartment of Environmental Chemistry, Faculty of Chemistry, University of Lodz, 163/165 Pomorska Str., 90-236 Łódź, Poland.ORCID 0000-0003-0071-1470

Justyna PiechockaDepartment of Environmental Chemistry, Faculty of Chemistry, University of Lodz, 163/165 Pomorska Str., 90-236 Łódź, Poland.ORCID 0000-0002-1160-3160

Funding

University of Lodz B2511100000234.01

6 · The paper itself

Abstract

The article presents the first method based on high-performance liquid chromatography and ultraviolet detection (HPLC-UV) for the determination of timonacic (thioproline, 1,3-thiazolidine-4-carboxylic acid, tPro) in pharmaceutical tablets and face care products (creams, sera, foundations, suncreams). Sample preparation primarily involves solid-liquid extraction (SLE) of tPro with 0.2 mol/L phosphate buffer pH 6, derivatization with 0.25 mol/L 2-chloro-1-methylquinolinium tetrafluoroborate (CMQT), followed by polytetrafluoroethylene (PTFE) membrane filtration. The chromatographic separation of the stable UV-absorbing 2-

Indexed as

CosmeticsThiazolidinesChromatography, High Pressure LiquidLimit of DetectionPharmaceutical PreparationsReproducibility of ResultsSpectrophotometry, UltravioletCosmeticsPharmaceutical PreparationsThiazolidines1,3-thiazolidine-4-carboxylic acid2-chloro-1-methylquinolinium tetrafluoroboratecosmeticshigh performance liquid chromatographypharmaceutical tabletstimonacic

Identifiers

PMID40807327

DOI10.3390/molecules30153152

PMCPMC12348203

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.