Evidence map›Paper›PMID 40807116›Full record

ReviewJournal of clinical medicine2025

Review of Neurostimulation Therapies for Obstructive Sleep Apnea: Hypoglossal Nerve Stimulation and Beyond.

Patrícia Dos Santos Cé, Maria Eduarda Schiestl Melo, Alan Alves Machado, Sarah Eden Ridge, Thomaz Fleury Curado

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Airway Anatomy and Surgical Management in Obstructive Sleep Apnea.Clinical and experimental otorhinolaryngology · 2026
    Review
  2. Clinical pathway implications of bilateral hypoglossal nerve stimulation for PAP-intolerant OSA.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Patrícia Dos Santos CéDepartment of Dentistry, University Hospital Polydoro Ernani de São Thiago, Federal University of Santa Catarina, Florianópolis 88036-800, Brazil.
Maria Eduarda Schiestl MeloDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis 88036-800, Brazil.ORCID 0009-0002-3307-2927
Alan Alves MachadoDepartment of Dentistry, Federal University of Santa Catarina, Florianópolis 88036-800, Brazil.ORCID 0009-0004-0864-0886
Sarah Eden RidgeDepartment of Otorhinolaryngology-Head and Neck Surgery, Case Western Reserve School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Thomaz Fleury CuradoDepartment of Otorhinolaryngology-Head and Neck Surgery, Case Western Reserve School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.ORCID 0000-0002-9315-0475

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is a sleep-related respiratory disorder characterized by partial or complete obstruction of the upper airway, typically resulting in a decrease in arterial oxygen saturation and repeated awakenings from sleep. It is the most common sleep-related respiratory disorder, affecting 9% to 38% of adults. OSA is associated with loss of tone, improper contraction of the tongue, and pharyngeal dilator muscles of the upper airway during sleep. The gold-standard treatment for moderate-to-severe OSA is continuous positive airway pressure (CPAP). However, many patients have poor long-term compliance with CPAP. Stimulation of the upper airway with electrical activation of the hypoglossal nerve has emerged as a promising treatment for patients with moderate-to-severe OSA who have failed CPAP therapy. Objectives: The present paper aims to review the literature regarding neurostimulation for the treatment of OSA. Conclusions: Hypoglossal nerve stimulation (HNS) has shown favorable success and low morbidity in the management of moderate-to-severe OSA.

Indexed as

airway managementhypoglossal nerve stimulationobstructive sleep apnea

Identifiers

PMID40807116
PMCPMC12347120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.