Evidence map›Paper›PMID 40806788›Full record

ArticleInternational journal of molecular sciences2025

Loss of SPRED3 Causes Primary Hypothyroidism and Alters Thyroidal Expression of Autophagy Regulators LC3, p62, and ATG5 in Mice.

Celine Dogan, Luisa Haas, Rebecca Holzapfel, Franziska Schmitt, Denis Hepbasli, Melanie Ullrich, Michael R Bösl, Marco Abeßer, Kai Schuh, Sina Gredy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Celine DoganInstitute of Physiology I, University Wuerzburg, Roentgenring 9, 97070 Wuerzburg, Germany.
Luisa HaasInstitute of Physiology I, University Wuerzburg, Roentgenring 9, 97070 Wuerzburg, Germany.
Rebecca HolzapfelInstitute of Experimental Biomedicine I, University Hospital Wuerzburg, Rudolf Virchow Center, University of Wuerzburg, 97080 Wuerzburg, Germany.
Franziska SchmittInstitute of Physiology I, University Wuerzburg, Roentgenring 9, 97070 Wuerzburg, Germany.
Denis HepbasliInstitute of Physiology I, University Wuerzburg, Roentgenring 9, 97070 Wuerzburg, Germany.
Melanie UllrichCenter for Rare Diseases, University Clinic Wuerzburg, Josef-Schneider-Strasse 2, 97080 Wuerzburg, Germany.
Michael R BöslInstitute of Experimental Biomedicine I, University Hospital Wuerzburg, Rudolf Virchow Center, University of Wuerzburg, 97080 Wuerzburg, Germany.ORCID 0000-0002-4448-1382
Marco AbeßerInstitute of Physiology I, University Wuerzburg, Roentgenring 9, 97070 Wuerzburg, Germany.
Kai SchuhInstitute of Physiology I, University Wuerzburg, Roentgenring 9, 97070 Wuerzburg, Germany.ORCID 0000-0003-4475-0412
Sina GredyInstitute of Physiology I, University Wuerzburg, Roentgenring 9, 97070 Wuerzburg, Germany.

Funding

Deutsche Forschungsgemeinschaft SCHU1600/6-1, 453989101
6 · The paper itself

Abstract

Sprouty-related proteins with enabled/vasodilator-stimulated phosphoprotein homology 1 (EVH1) domain (SPREDs) are negative regulators of the Ras/MAPK signaling pathway and are known to modulate developmental and endocrine processes. While the roles of SPRED1 and SPRED2 are increasingly understood, the physiological relevance of SPRED3 remains elusive. To elucidate its function, we generated SPRED3 knockout (KO) mice and performed phenotypic, molecular, and hormonal analyses. SPRED3-deficient mice exhibited growth retardation and a non-Mendelian genotype distribution. X-Gal staining revealed

Indexed as

AutophagyAutophagy-Related Protein 5HypothyroidismMicrotubule-Associated ProteinsSequestosome-1 ProteinThyroid GlandAnimalsMaleMiceMice, KnockoutAtg5 protein, mouseAutophagy-Related Protein 5Map1lc3b protein, mouseMicrotubule-Associated ProteinsSequestosome-1 ProteinSqstm1 protein, mouseautophagyhypothyroidismKO miceSPREDSPRED3

Identifiers

PMID40806788
PMCPMC12347450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.