Evidence map›Paper›PMID 40806760›Full record

ArticleInternational journal of molecular sciences2025

Pro-Reparative Effects of KvLQT1 Potassium Channel Activation in a Mouse Model of Acute Lung Injury Induced by Bleomycin.

Tom Voisin, Alban Girault, Mélissa Aubin Vega, Émilie Meunier, Jasmine Chebli, Anik Privé, Damien Adam, Emmanuelle Brochiero

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tom VoisinCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.ORCID 0000-0001-6846-9110
Alban GiraultLaboratoire de Physiologie Cellulaire et Moléculaire (LPCM UR UPJV 4667), 80039 Amiens Cedex, France.ORCID 0000-0001-5478-9340
Mélissa Aubin VegaCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.
Émilie MeunierCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.
Jasmine ChebliCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.
Anik PrivéCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.
Damien AdamCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.ORCID 0000-0003-3665-2652
Emmanuelle BrochieroCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.ORCID 0000-0002-8182-943X

Funding

CIHR MOP-111054, PJT153406 and PTJ166004Natural Sciences and Engineering Research Council RGPIN-2016-04378 and RGPIN-2023-04496
6 · The paper itself

Abstract

Acute Respiratory Distress Syndrome (ARDS) is a complex and devastating form of respiratory failure, with high mortality rates, for which there is no pharmacological treatment. The acute exudative phase of ARDS is characterized by severe damage to the alveolar-capillary barrier, infiltration of protein-rich fluid into the lungs, neutrophil recruitment, and high levels of inflammatory mediators. Rapid resolution of this reversible acute phase, with efficient restoration of alveolar functional integrity, is essential before the establishment of irreversible fibrosis and respiratory failure. Several lines of in vitro and in vivo evidence support the involvement of potassium (K

Indexed as

Acute Lung InjuryBleomycinKCNQ1 Potassium ChannelAnimalsDisease Models, AnimalLungMaleMiceMice, Inbred C57BLRespiratory Distress SyndromeBleomycinKCNQ1 Potassium Channelacute lung injuryalveolar–capillary barrieranimal modelepithelial injury and repairpotassium channelspulmonary inflammation

Identifiers

PMID40806760
PMCPMC12347741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.