Evidence map›Paper›PMID 40806748›Full record

ArticleInternational journal of molecular sciences2025

Role of Endogenous Galectin-3 on Cell Biology of Immortalized Retinal Pigment Epithelial Cells In Vitro.

Caspar Liesenhoff, Marlene Hillenmayer, Caroline Havertz, Arie Geerlof, Daniela Hartmann, Siegfried G Priglinger, Claudia S Priglinger, Andreas Ohlmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Galectin-3 Mediates TGF-β-Controlled Migration in Müller Glial Cells.International journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caspar LiesenhoffDepartment of Ophthalmology, University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
Marlene HillenmayerDepartment of Ophthalmology, University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
Caroline HavertzDepartment of Ophthalmology, University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
Arie GeerlofProtein Expression and Purification Facility, Institute of Structural Biology, Helmholtz Center Munich for Environmental Health, 85764 Neuherberg, Germany.ORCID 0000-0001-7295-9948
Daniela HartmannDepartment of Dermatology and Allergy, LMU University Hospital, Ludwig-Maximilians-University Munich, 80337 Munich, Germany.ORCID 0000-0002-1002-8133
Siegfried G PriglingerDepartment of Ophthalmology, University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.ORCID 0000-0002-5580-612X
Claudia S PriglingerDepartment of Ophthalmology, University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.ORCID 0000-0003-1847-3626
Andreas OhlmannDepartment of Ophthalmology, University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.ORCID 0000-0002-7101-9361

Funding

Deutsche Forschungsgemeinschaft OH 214/4-3;Deutsche Forschungsgemeinschaft PR 1248/2-3
6 · The paper itself

Abstract

Galectin-3 is a multifunctional protein that is associated with diseases of the chorioretinal interface, in which the retinal pigment epithelium (RPE) plays a central role in disease development and progression. Since galectin-3 can function extracellularly as well as intracellularly via different mechanisms, we developed an immortalized human RPE cell line (ARPE-19) with a knockdown for galectin-3 expression (ARPE-19/LGALS3

Indexed as

Epithelial CellsGalectin 3Retinal Pigment Epitheliumbeta CateninBlood ProteinsCadherinsCell AdhesionCell LineCell ProliferationEpithelial-Mesenchymal TransitionGalectinsHumansProto-Oncogene Proteins c-aktbeta CateninBlood ProteinsCadherinsGalectin 3GalectinsLGALS3 protein, humanProto-Oncogene Proteins c-aktAKT signalingARPE-19cell attachmentcell proliferationEMTERK signalinggalectin-3galectin-3 knockdownretinal pigment epithelium cellsβ-catenin signaling

Identifiers

PMID40806748
PMCPMC12347958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.