Evidence map›Paper›PMID 40806726›Full record

ArticleInternational journal of molecular sciences2025

Phage Host Range Expansion Through Directed Evolution on Highly Phage-Resistant Strains of

Kevin A Burke, Tracey L Peters, Olga A Kirillina, Caitlin D Urick, Bertran D Walton, Jordan T Bird, Nino Mzhavia, Martin O Georges, Paphavee Lertsethtakarn, Lillian A Musila and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kevin A BurkeWound Infections Department, Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Tracey L PetersDepartment of Entomology, College of Agricultural, Human and Natural Resource Sciences, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0003-4644-8743
Olga A KirillinaWound Infections Department, Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Caitlin D UrickWound Infections Department, Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0009-0008-7696-1808
Bertran D WaltonWound Infections Department, Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Jordan T BirdDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.ORCID 0000-0001-5753-6058
Nino MzhaviaWound Infections Department, Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Martin O GeorgesDepartment of Emerging Infectious Diseases, Walter Reed Army Institute of Research-Africa, Nairobi P.O. Box 606-00621, Kenya.
Paphavee LertsethtakarnDepartment of Bacterial and Parasitic Diseases, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.ORCID 0000-0003-2993-9794
Lillian A MusilaDepartment of Emerging Infectious Diseases, Walter Reed Army Institute of Research-Africa, Nairobi P.O. Box 606-00621, Kenya.ORCID 0000-0003-1418-6523
Mikeljon P NikolichWound Infections Department, Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-5770-8980
Andrey A FilippovWound Infections Department, Bacterial Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0003-2256-861X

Funding

DoD Congressionally Directed Medical Research Programs, Peer Reviewed Medical Research Program PR182667Military Infectious Diseases Research Program MI210045
6 · The paper itself

Abstract

Multidrug-resistant (MDR) strains of

Indexed as

BacteriophagesDirected Molecular EvolutionHost SpecificityKlebsiella pneumoniaeGenome, ViralKlebsiella InfectionsMutationPhage TherapyAppelmans protocoldefined mutations and recombination eventshost range expansionJiaodavirusKlebsiella pneumoniaephage cocktail improvementphage training

Identifiers

PMID40806726
PMCPMC12347782

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.