Evidence map›Paper›PMID 40806719›Full record

ArticleInternational journal of molecular sciences2025

Chronic Low Back Pain in Young Adults: Pathophysiological Aspects of Neuroinflammation and Degeneration.

Natalya G Pravdyuk, Anastasiia A Buianova, Anna V Novikova, Alesya A Klimenko, Mikhail A Ignatyuk, Liubov A Malykhina, Olga I Patsap, Dmitrii A Atiakshin, Vitaliy T Timofeev, Nadezhda A Shostak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natalya G PravdyukAcad. A. I. Nesterov Department of Faculty Therapy, Pirogov Russian National Research Medical University, 1, Ostrovityanova St., 117997 Moscow, Russia.
Anastasiia A BuianovaResearch and Educational Resource Centre for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia.ORCID 0000-0001-7894-9222
Anna V NovikovaAcad. A. I. Nesterov Department of Faculty Therapy, Pirogov Russian National Research Medical University, 1, Ostrovityanova St., 117997 Moscow, Russia.ORCID 0000-0002-8104-9791
Alesya A KlimenkoAcad. A. I. Nesterov Department of Faculty Therapy, Pirogov Russian National Research Medical University, 1, Ostrovityanova St., 117997 Moscow, Russia.ORCID 0000-0002-7410-9784
Mikhail A IgnatyukResearch and Educational Resource Centre for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia.
Liubov A MalykhinaResearch and Educational Resource Centre for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia.
Olga I PatsapResearch and Educational Resource Centre for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia.
Dmitrii A AtiakshinResearch and Educational Resource Centre for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, Russia.ORCID 0000-0002-8347-4556
Vitaliy T TimofeevScientific Research Laboratory of Rheumatic Disease, Pirogov Russian National Research Medical University, 1, Ostrovityanova St., 117997 Moscow, Russia.
Nadezhda A ShostakAcad. A. I. Nesterov Department of Faculty Therapy, Pirogov Russian National Research Medical University, 1, Ostrovityanova St., 117997 Moscow, Russia.

Funding

State assignment for Acad. A. I. Nesterov Department of Faculty Therapy, Pirogov Russian Na-tional Research Medical University 04200729490
6 · The paper itself

Abstract

Degenerative disc disease (DDD) is a major cause of chronic low back pain (LBP), yet the molecular mechanisms driving disc degeneration and pain remain poorly understood. This study analyzed intervertebral disc (IVD) tissue from 36 young patients (median age = 36.00 [31.00, 42.50] years) with herniated discs and LBP, alongside healthy controls, to investigate changes in the extracellular matrix (ECM) and neurochemical alterations. Disc degeneration was assessed using MRI (Pfirrmann grading) and histology (Sive's criteria). Histochemical and immunohistochemical methods were used to evaluate aggrecan content, calcification, and the expression of nerve growth factor (NGF), substance P (SP), and S-100 protein. MRI findings included Pfirrmann grades V (30.55%), IV (61.11%), III (5.56%), and II (2.78%). Severe histological degeneration (10-12 points) was observed in three patients. Aggrecan depletion correlated with longer pain duration (r = 0.449,

Indexed as

Chronic PainIntervertebral Disc DegenerationLow Back PainNeuroinflammatory DiseasesAdultAggrecansExtracellular MatrixFemaleHumansIntervertebral DiscMagnetic Resonance ImagingMaleNerve Growth FactorSubstance PYoung AdultAggrecansNerve Growth FactorSubstance Paggrecanback paincalcificationdegenerative disc diseaseimmunohistochemistryNGFS-100substance Pyoung age

Identifiers

PMID40806719
PMCPMC12347870

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.