Evidence map›Paper›PMID 40806703›Full record

ArticleInternational journal of molecular sciences2025

Biomarkers of Metabolism and Inflammation in Individuals with Obesity and Normal Weight: A Comparative Analysis Exploring Sex Differences.

Eveline Gart, Jessica Snabel, Jelle C B C de Jong, Lars Verschuren, Anita M van den Hoek, Martine C Morrison, Robert Kleemann

Abstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eveline GartDepartment of Metabolic Health Research, The Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.ORCID 0000-0002-7713-2381
Jessica SnabelDepartment of Metabolic Health Research, The Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.
Jelle C B C de JongDepartment of Microbiology and Systems Biology, The Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.ORCID 0000-0002-5154-4900
Lars VerschurenDepartment of Microbiology and Systems Biology, The Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.ORCID 0000-0002-7847-9037
Anita M van den HoekDepartment of Metabolic Health Research, The Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.ORCID 0000-0002-7077-8446
Martine C MorrisonDepartment of Metabolic Health Research, The Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.ORCID 0000-0003-4996-943X
Robert KleemannDepartment of Metabolic Health Research, The Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands.ORCID 0000-0002-1350-0149

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood-based biomarkers allow monitoring of an individual's health status and provide insights into metabolic and inflammatory processes in conditions like obesity, cardiovascular, and liver diseases. However, selecting suitable biomarkers and optimizing analytical assays presents challenges, is time-consuming and laborious. Moreover, knowledge of potential sex differences remains incomplete as research is often carried out in men. This study aims at enabling researchers to make informed choices on the type of biomarkers, analytical assays, and dilutions being used. More specifically, we analyzed plasma concentrations of >90 biomarkers using commonly available ELISA or electrochemiluminescence-based multiplex methods, comparing normal weight (BMI < 25;

Indexed as

BiomarkersInflammationObesityAdipokinesAdultBody Mass IndexFemaleHumansMaleMiddle AgedSex CharacteristicsSex FactorsAdipokinesBiomarkersimmunoassaysmetabolic risk factorsobesitysex differences

Identifiers

PMID40806703
PMCPMC12347797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.