Antimicrobial Photodynamic Activity of the Zn(II) Phthalocyanine RLP068/Cl Versus Antimicrobial-Resistant Priority Pathogens.

Ilaria Baccani, Sara Cuffari, Francesco Giuliani, Gian Maria Rossolini, Simona Pollini

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ilaria BaccaniDepartment of Experimental and Clinical Medicine (DMSC), University of Florence, Largo Brambilla, 3, 50134 Florence, FI, Italy.

Sara CuffariDepartment of Experimental and Clinical Medicine (DMSC), University of Florence, Largo Brambilla, 3, 50134 Florence, FI, Italy.

Francesco GiulianiL. Molteni & C. dei Fratelli Alitti, Società di esercizio S.P.A. SS57 Loc. granatieri, 50018 Scandicci, FI, Italy.

Gian Maria RossoliniDepartment of Experimental and Clinical Medicine (DMSC), University of Florence, Largo Brambilla, 3, 50134 Florence, FI, Italy.ORCID 0000-0002-9386-0434

Simona PolliniDepartment of Experimental and Clinical Medicine (DMSC), University of Florence, Largo Brambilla, 3, 50134 Florence, FI, Italy.

Funding

Molteni Therapeutics B14I20001570007

6 · The paper itself

Abstract

The emergence and spread of antimicrobial resistance among pathogens are significantly reducing available therapeutic options, highlighting the urgent need for novel and complementary treatment strategies. Antimicrobial photodynamic therapy (aPDT) is a promising alternative approach that can overcome antimicrobial resistance through a multitarget mechanism of action, exerting direct bactericidal and fungicidal effects with minimal risk of resistance development. Although aPDT has shown efficacy against a variety of pathogens, data on its activity against large collections of clinical multidrug-resistant strains are still limited. In this study, we assessed the antimicrobial activity of the photosensitizer RLP068/Cl combined with a red light-emitting LED source at 630 nm (Molteni Farmaceutici, Italy) against a large panel of Gram-negative and Gram-positive bacterial strains harboring relevant resistance traits and

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsIndolesOrganometallic CompoundsPhotosensitizing AgentsCandidaGram-Negative BacteriaGram-Positive BacteriaIsoindolesMicrobial Sensitivity TestsPhotochemotherapyZinc CompoundsAnti-Bacterial AgentsAnti-Infective AgentsIndolesIsoindolesOrganometallic CompoundsPhotosensitizing AgentsZinc CompoundsZn(II)-phthalocyaninemultidrug-resistant pathogensphotoinactivationZn(II) phthalocyanine

Identifiers

PMID40806672

DOI10.3390/ijms26157545

PMCPMC12347331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.