ArticleInternational journal of molecular sciences2025
Upregulating ANKHD1 in PS19 Mice Reduces Tau Phosphorylation and Mitigates Tau Toxicity-Induced Cognitive Deficits.
Xiaolin Tian, Nathan Le, Yuhai Zhao, Dina Alawamleh, Andrew Schwartz, Lauren Meyer, Elizabeth Helm, Chunlai Wu
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Xiaolin TianNeuroscience Center of Excellence, Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.ORCID 0000-0001-8898-1664 Nathan LeNeuroscience Center of Excellence, Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Yuhai ZhaoNeuroscience Center of Excellence, Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Dina AlawamlehNeuroscience Center of Excellence, Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Andrew SchwartzNeuroscience Center of Excellence, Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Lauren MeyerLouisiana State University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.
Elizabeth HelmLouisiana State University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.
Chunlai WuNeuroscience Center of Excellence, Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.ORCID 0000-0002-2574-9486 Funding
Enhancing Mask/ANKHD1 activity to protect against Tau-induced neurodegenerationR21NS123861 · NINDS · LSU HEALTH SCIENCES CENTER · PI WU, CHUNLAI · 2021 to 2021
$404kNIH/NINDS NS123861NINDS NIH HHS R21 NS123861
6 · The paper itselfAbstract
Using the fly eye as a model system, we previously demonstrated that upregulation of the fly gene
Indexed as
Cognitive DysfunctionTauopathiestau ProteinsAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicPhosphorylationUp-Regulationtau ProteinsANKHD1cognitive deficitsPS19 mouseTau phosphorylation
Identifiers
PMID40806649
PMCPMC12347928
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