Evidence map›Paper›PMID 40806643›Full record

ReviewInternational journal of molecular sciences2025

Molecular Mechanisms of Cadmium-Induced Toxicity and Its Modification.

Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Application of Modulators of CaInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jin-Yong LeeLaboratory of Public Health, School of Pharmacy, Aichi Gakuin University, Kusumoto-cho 1-100, Chikusa-ku, Nagoya 464-8650, Japan.
Maki TokumotoLaboratory of Public Health, School of Pharmacy, Aichi Gakuin University, Kusumoto-cho 1-100, Chikusa-ku, Nagoya 464-8650, Japan.ORCID 0000-0002-8177-298X
Masahiko SatohLaboratory of Public Health, School of Pharmacy, Aichi Gakuin University, Kusumoto-cho 1-100, Chikusa-ku, Nagoya 464-8650, Japan.

Funding

Japan Society for the Promotion of Science 20390175the Health Effects of Heavy Metals, organized by the Ministry of the Environment, Japan 20252043004
6 · The paper itself

Abstract

Cadmium (Cd) is a toxic environmental heavy metal that exerts harmful effects on multiple tissues, including the kidney, liver, lung, and bone, and is also associated with the development of anemia. However, the precise molecular mechanisms underlying Cd-induced toxicity remain incompletely understood. In this paper, we review the recent molecular mechanisms of Cd-induced toxicity and its modification, with a particular emphasis on our recent findings. Using a combination of DNA microarray analysis, protein-DNA binding assays, and siRNA-mediated gene silencing, we identified several transcription factors, YY1, FOXF1, ARNT, and MEF2A, as novel molecular targets of Cd. The downregulation of their downstream genes, including

Indexed as

CadmiumAnimalsApoptosisHumansIronSignal TransductionCadmiumIronapoptosiscadmiumiron deficiency anemiarenal toxicitytranscript pathway

Identifiers

PMID40806643
PMCPMC12347203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.