Evidence map›Paper›PMID 40806633›Full record

ArticleInternational journal of molecular sciences2025

Genetic Associations of

Eun Ju Ko, Eun Hee Ahn, Hyeon Woo Park, Jae Hyun Lee, Da Hwan Kim, Young Ran Kim, Ji Hyang Kim, Nam Keun Kim

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eun Ju KoDivision of Life Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Eun Hee AhnDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam 13596, Republic of Korea.
Hyeon Woo ParkDivision of Life Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Jae Hyun LeeDivision of Life Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Da Hwan KimDivision of Life Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Young Ran KimDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam 13596, Republic of Korea.ORCID 0000-0001-8431-7563
Ji Hyang KimDepartment of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam 13596, Republic of Korea.ORCID 0000-0002-9864-9777
Nam Keun KimDivision of Life Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.ORCID 0000-0003-0541-3528

Funding

Korea Health Industry Development Institute HR22C1605National Research Foundation of Korea 2022R1F1A1064169National Research Foundation of Korea 2022R1F1A1076255National Research Foundation of Korea RS-2023-00246879
6 · The paper itself

Abstract

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more pregnancy losses before 20 weeks of gestation. RPL is a common medical condition among reproductive-age women, with approximately 23 million cases reported annually worldwide. Up to 5% of pregnant women may experience two or more consecutive pregnancy losses. Previous studies have investigated risk factors for RPL, including maternal age, uterine pathology, genetic anomalies, infectious agents, endocrine disorders, thrombophilia, and immune dysfunction. However, RPL is a disease caused by a complex interaction of genetic factors, environmental factors (e.g., diet, lifestyle, and stress), epigenetic factors, and the immune system. In addition, due to the lack of research on genetics research related to RPL, the etiology remains unclear in up to 50% of cases. Platelets play a critical role in pregnancy maintenance. This study examined the associations of platelet receptor and ligand gene variants, including integrin subunit beta 3 (

Indexed as

Abortion, HabitualFibrinogenIntegrin beta3Platelet ActivationPolymorphism, Single NucleotideReceptors, Cell SurfaceAdultCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansPlatelet Glycoprotein GPIb-IX ComplexPregnancyRepublic of KoreaFibrinogenIntegrin beta3ITGB3 protein, humanPEAR1 protein, humanPlatelet Glycoprotein GPIb-IX ComplexReceptors, Cell Surfaceallele combinationgenotype combinationplatelet activationrecurrent pregnancy losssingle-nucleotide polymorphism

Identifiers

PMID40806633
PMCPMC12347128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.