Evidence map›Paper›PMID 40806597›Full record

ArticleInternational journal of molecular sciences2025

A Comparative Analysis of Usual- and Gastric-Type Cervical Adenocarcinoma in a Japanese Population Reveals Distinct Clinicopathological and Molecular Features with Prognostic and Therapeutic Insights.

Umme Farzana Zahan, Hasibul Islam Sohel, Kentaro Nakayama, Masako Ishikawa, Mamiko Nagase, Sultana Razia, Kosuke Kanno, Hitomi Yamashita, Shahataj Begum Sonia, Satoru Kyo

Abstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. HPV-Independent Cervical Cancer-A New Challenge of Modern Oncology.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Umme Farzana ZahanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0009-0008-7147-8569
Hasibul Islam SohelDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0009-0008-8987-9686
Kentaro NakayamaDepartment of Obstetrics and Gynecology, East Medical Center, Nagoya City University, Nagoya 464-8547, Japan.ORCID 0000-0002-3250-3097
Masako IshikawaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Mamiko NagaseDepartment of Organ Pathology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Sultana RaziaDepartment of Legal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-Cho, Izumo 693-8501, Japan.
Kosuke KannoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Hitomi YamashitaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Shahataj Begum SoniaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0009-0005-9983-5810
Satoru KyoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0000-0002-8986-6147

Funding

Japan Society for the Promotion of Science 24K02588
6 · The paper itself

Abstract

Gastric-type cervical adenocarcinoma (GCA) is a rare and aggressive subtype of cervical adenocarcinoma. Despite its clinical significance, its molecular carcinogenesis and therapeutic targets remain poorly understood. This study aimed to compare the clinicopathological, immunohistochemical, and molecular profiles of GCA and usual-type cervical adenocarcinoma (UCA), exploring prognostic and therapeutic biomarkers in a Japanese population. A total of 110 cervical adenocarcinoma cases, including 16 GCA and 94 UCA cases, were retrospectively analyzed for clinicopathological features, and a panel of immunohistochemical markers was assessed. Sanger sequences were performed for the

Indexed as

AdenocarcinomaUterine Cervical NeoplasmsAdultAgedB7-H1 AntigenBiomarkers, TumorClass I Phosphatidylinositol 3-KinasesEast Asian PeopleFemaleHumansJapanMiddle AgedMutationPrognosisProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)B7-H1 AntigenBiomarkers, TumorBRAF protein, humanCD274 protein, humanClass I Phosphatidylinositol 3-KinasesKRAS protein, humanPIK3CA protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)ARID1Bgastric-type cervical adenocarcinomaimmune checkpoint inhibitor (ICI) therapyprognostic biomarkerusual-type cervical adenocarcinoma

Identifiers

PMID40806597
PMCPMC12347983

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.