Evidence map›Paper›PMID 40806579›Full record

ArticleInternational journal of molecular sciences2025

APTIMA mRNA vs. DNA-Based HPV Assays: Analytical Performance Insights from a Resource-Limited South African Setting.

Varsetile Varster Nkwinika, Kelvin Amoh Amissah, Johnny Nare Rakgole, Moshawa Calvin Khaba, Cliff Abdul Magwira, Ramokone Lisbeth Lebelo

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Varsetile Varster NkwinikaDepartment of Virological Pathology, Sefako Makgatho Health Sciences University, Medunsa, P.O. Box 60, Pretoria 0204, South Africa.ORCID 0000-0002-8294-9089
Kelvin Amoh AmissahDepartment of Virological Pathology, Sefako Makgatho Health Sciences University, Medunsa, P.O. Box 60, Pretoria 0204, South Africa.
Johnny Nare RakgoleDepartment of Virological Pathology, Sefako Makgatho Health Sciences University, Medunsa, P.O. Box 60, Pretoria 0204, South Africa.
Moshawa Calvin KhabaDepartment of Anatomical Pathology, Sefako Makgatho Health Sciences University, Medunsa, P.O. Box 60, Pretoria 0204, South Africa.ORCID 0000-0001-6999-6836
Cliff Abdul MagwiraDepartment of Virological Pathology, Sefako Makgatho Health Sciences University, Medunsa, P.O. Box 60, Pretoria 0204, South Africa.ORCID 0000-0002-4081-6886
Ramokone Lisbeth LebeloDepartment of Virological Pathology, Sefako Makgatho Health Sciences University, Medunsa, P.O. Box 60, Pretoria 0204, South Africa.ORCID 0000-0002-9365-514X

Funding

National Health Laboratory Service GRANT004_94740Vlaamse Interuniversitaire Raad VLIR-UOS ZIUS2015AP021
6 · The paper itself

Abstract

Cervical cancer remains a major health burden among women in sub-Saharan Africa, where screening is often limited. Persistent high-risk human papillomavirus (HR-HPV) infection is the principal cause, highlighting the need for accurate molecular diagnostics. This cross-sectional study evaluated the analytical performance of one mRNA assay, APTIMA

Indexed as

DNA, ViralMolecular Diagnostic TechniquesPapillomaviridaePapillomavirus InfectionsRNA, MessengerUterine Cervical NeoplasmsAdultCross-Sectional StudiesFemaleGenotypeHumansMiddle AgedSensitivity and SpecificitySouth AfricaYoung AdultDNA, ViralRNA, Messengeranalytical performancecervical cancer screeningE6/E7 mRNAHPV DNASouth Africa

Identifiers

PMID40806579
PMCPMC12347973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.