Evidence map›Paper›PMID 40806494›Full record

ArticleInternational journal of molecular sciences2025

Growth Hormone Therapy in Recurrent Implantation Failure: Stratification by FSH Receptor Polymorphism (Asn680Ser) Reveals Genotype-Specific Benefits.

Mihai Surcel, Georgiana Nemeti, Iulian Gabriel Goidescu, Romeo Micu, Cristina Zlatescu-Marton, Ariana Anamaria Cordos, Gabriela Caracostea, Ioana Cristina Rotar, Daniel Muresan, Dan Boitor-Borza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mihai SurcelObstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.ORCID 0000-0003-4922-3013
Georgiana NemetiObstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.ORCID 0000-0002-8567-1246
Iulian Gabriel GoidescuObstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.ORCID 0000-0002-6106-816X
Romeo MicuObstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Cristina Zlatescu-Marton"Regina Maria" Hospital, 29 Dorobantilor Street, 400117 Cluj-Napoca, Romania.
Ariana Anamaria CordosMedical Informatics and Biostatistics, Department XII-Medical Education, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Gabriela CaracosteaDepartamentul de Kinetoterapie și Motricitate Specială, Facultatea de Educație Fizică și Sport, Universitatea Babeș-Bolyai, 400347 Cluj-Napoca, Romania.ORCID 0000-0002-0011-8522
Ioana Cristina RotarObstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.ORCID 0000-0002-7700-2384
Daniel MuresanObstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Dan Boitor-BorzaObstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.ORCID 0000-0001-6832-9898

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent implantation failure (RIF) remains a challenging clinical problem. Growth hormone (GH) co-treatment has been explored as an adjunct in poor responders and RIF patients, with inconsistent evidence of benefit. This prospective cohort study assessed the impact of GH supplementation in 91 RIF patients undergoing in vitro fertilization, stratified by FSHR (follicular stimulating hormone receptor) genotype

Indexed as

Embryo ImplantationGrowth HormoneReceptors, FSHAdultFemaleFertilization in VitroGenotypeHumansPregnancyProspective StudiesFSHR protein, humanGrowth HormoneReceptors, FSHendometrial dysfunctionFSH receptorgenotype Asn680Sergrowth hormoneleukemia inhibitory factorprogesteronerecurrent implantation failure

Identifiers

PMID40806494
PMCPMC12347810

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.