Evidence map›Paper›PMID 40806454›Full record

ReviewInternational journal of molecular sciences2025

A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy.

Atena Yaramiri, Rand Abo Asalh, Majd Abo Asalh, Nour AlSawaftah, Waad H Abuwatfa, Ghaleb A Husseini

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Spatiotemporal cancer controlNanomedicine (London, England) · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Atena YaramiriBiomedical Engineering Program, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Rand Abo AsalhInternal Medicine Residency, Internal Medicine Department, Manatee Memorial Hospital, Bradenton, FL 34208, USA.
Majd Abo AsalhInternal Medicine Residency, Internal Medicine Department, Manatee Memorial Hospital, Bradenton, FL 34208, USA.
Nour AlSawaftahMaterial Science and Engineering Ph. D. Program, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Waad H AbuwatfaMaterial Science and Engineering Ph. D. Program, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.ORCID 0000-0002-2424-1736
Ghaleb A HusseiniBiomedical Engineering Program, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.ORCID 0000-0002-7244-3105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By 2030, millions of new cancer cases will be diagnosed, as well as millions of cancer-related deaths. Traditional drug delivery methods have limitations, so developing smart drug delivery systems (SDDs) has emerged as a promising avenue for more effective and precise cancer treatment. Nanotechnology, particularly nanomedicine, provides innovative approaches to enhance drug delivery, including the use of nanoparticles. One such type of SDD is thermosensitive nanoparticles, which respond to internal and external stimuli, such as temperature changes, to release drugs precisely at tumor sites and minimize off-target effects. On the other hand, hyperthermia is a cancer treatment mode that goes back centuries and has become popular because it can target cancer cells while sparing healthy tissue. This paper presents a comprehensive review of smart thermosensitive nanoparticles for cancer treatment, with a primary focus on organic nanoparticles. The integration of hyperthermia with temperature-sensitive nanocarriers, such as micelles, hydrogels, dendrimers, liposomes, and solid lipid nanoparticles, offers a promising approach to improving the precision and efficacy of cancer therapy. By leveraging temperature as a controlled drug release mechanism, this review highlights the potential of these innovative systems to enhance treatment outcomes while minimizing adverse side effects.

Indexed as

Drug CarriersNanoparticlesNeoplasmsPrecision MedicineAnimalsAntineoplastic AgentsDrug Delivery SystemsHumansHyperthermia, InducedLiposomesMicellesNanomedicineAntineoplastic AgentsDrug CarriersLiposomesMicellescancer treatmentdrug deliveryhyperthermiananotechnologysmart drug delivery systemsthermosensitive nanocarriers

Identifiers

PMID40806454
PMCPMC12347689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.