Evidence map›Paper›PMID 40806445›Full record

ArticleInternational journal of molecular sciences2025

Impact of Obesity and Ageing on the Expression of Key Mediators of SARS-CoV-2 Infection in Human Adipose Tissue.

Maria Salazar, Mariana Ferreira, Sandra Marisa Oliveira, Francisca Saraiva, Carlos Pinho, Mariana Jarnalo, Inês Correia-Sá, Inês Falcão-Pires, Adelino Leite-Moreira, Delminda Neves and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria SalazarUnidade de Biologia Experimental, Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0001-6568-1917
Mariana FerreiraUnidade de Biologia Experimental, Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
Sandra Marisa OliveiraCardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0002-3504-5749
Francisca SaraivaCardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
Carlos PinhoDepartment of Plastic and Reconstructive Surgery, Instituto Português de Oncologia do Porto FG, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.ORCID 0000-0002-5574-4459
Mariana JarnaloDepartment of Plastic and Reconstructive Surgery, Instituto Português de Oncologia do Porto FG, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.
Inês Correia-SáDepartment of Plastic, Reconstructive and Aesthetic Surgery, and Burn Unit, Centro Hospitalar e Universitário de São João, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
Inês Falcão-PiresCardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0003-1937-3782
Adelino Leite-MoreiraCardiovascular R&D Centre-UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0001-7808-3596
Delminda NevesUnidade de Biologia Experimental, Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0002-3301-8376
Henrique AlmeidaUnidade de Biologia Experimental, Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0002-3036-3211
Adriana R RodriguesUnidade de Biologia Experimental, Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0002-9613-1552
Alexandra M GouveiaUnidade de Biologia Experimental, Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0001-8784-4246

Funding

Fundação para a Ciência e Tecnologia DOI 10.54499/2020.10112.BD, DOI 10.54499/DL57/2016/CP1355/CT0009, UIDB/00051/2020 and UIDP/00051/2020
6 · The paper itself

Abstract

Increased body mass index (BMI) and age are associated with COVID-19 severity. SARS-CoV-2 infection occurs through ACE2 binding, with TMPRSS2, ADAM17, and NRP1 facilitating this process. This study describes how adipose tissue (AT) location, BMI, age, and obesity affect these proteins' expression. AT was collected from subcutaneous (abdominal superficial [AS], abdominal deep [AD], thigh [T]) and visceral (epiploon [E]) areas from middle-aged women without obesity (BMI 23.9 kg/m

Indexed as

Adipose TissueAgingCOVID-19ObesityADAM17 ProteinAgedAngiotensin-Converting Enzyme 2Body Mass IndexFemaleHumansMiddle AgedNeuropilin-1SARS-CoV-2Serine EndopeptidasesACE2 protein, humanADAM17 ProteinADAM17 protein, humanAngiotensin-Converting Enzyme 2Neuropilin-1NRP1 protein, humanSerine EndopeptidasesTMPRSS2 protein, humanACE2ADAM17adipose tissueageingCOVID-19NRP1obesitySARS-CoV-2 receptorsTMPRSS2

Identifiers

PMID40806445
PMCPMC12347392

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.