Dysregulated Alternative Splicing in Breast Cancer Subtypes of RIF1 and Other Transcripts.

Emma Parker, Laura Akintche, Alexandra Pyatnitskaya, Shin-Ichiro Hiraga, Anne D Donaldson

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emma ParkerChromosome & Cellular Dynamics Section, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Laura AkintcheChromosome & Cellular Dynamics Section, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Alexandra PyatnitskayaChromosome & Cellular Dynamics Section, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Shin-Ichiro HiragaChromosome & Cellular Dynamics Section, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.ORCID 0000-0002-8722-3869

Anne D DonaldsonChromosome & Cellular Dynamics Section, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Funding

Cancer Research Aberdeen & North-East Scotland (CRANES) UnknownCancer Research UK DRCPGM\100013

6 · The paper itself

Abstract

Genome instability is a hallmark of cancer, often driven by mutations and altered expression of genome maintenance factors involved in DNA replication and repair. Rap1 Interacting Factor 1 (RIF1) plays a crucial role in genome stability and is implicated in cancer pathogenesis. Cells express two RIF1 splice variants, RIF1-Long and RIF1-Short, which differ in their ability to protect cells from DNA replication stress. Here, we investigate differential expression and splicing of RIF1 in cancer cell lines following replication stress and in patients using matched normal and tumour data from The Cancer Genome Atlas (TCGA). Overall

Indexed as

Alternative SplicingBreast NeoplasmsGene Expression Regulation, NeoplasticTelomere-Binding ProteinsCell Line, TumorExonsFemaleHumansRif1 protein, humanTelomere-Binding Proteinsbreast cancerRNA splicingTCGA

Identifiers

PMID40806439

DOI10.3390/ijms26157308

PMCPMC12347697

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.