Evidence map›Paper›PMID 40806430›Full record

ArticleInternational journal of molecular sciences2025

Lifetime Variations in Prolactin Expression in the Hippocampus and Dentate Gyrus of the Rat.

Marta Carretero-Hernández, Elisa Herráez, Leonardo Catalano-Iniesta, David Hernández-González, David Díez-Castro, Ana E Rodríguez-Vicente, Josefa García-Barrado, Teresa Vicente-García, Miguel Robles-García, Enrique J Blanco and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Aging and Thymosin Alpha-1.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marta Carretero-HernándezDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-0712-2804
Elisa HerráezDepartment of Physiology and Pharmacology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-9271-3320
Leonardo Catalano-IniestaDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-1957-1762
David Hernández-GonzálezDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.
David Díez-CastroDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-0474-3672
Ana E Rodríguez-VicenteDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-6516-2172
Josefa García-BarradoLaboratory of Neuroendocrinology, Institute of Neuroscience of Castilla y León, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-2552-5973
Teresa Vicente-GarcíaDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0009-0009-6412-5850
Miguel Robles-GarcíaDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0001-8670-7653
Enrique J BlancoDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-5332-4282
José CarreteroDepartment of Human Anatomy and Histology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain.

Funding

Junta de Castilla y León 2018/00221/001
6 · The paper itself

Abstract

Prolactin is a hormone with demonstrated roles in the brain, including neurogenesis, neuroprotection, learning, stress response or memory consolidation. To determine the prolactin expression in the rat hippocampus during aging and to resolve some controversies related to the presence of prolactin in the hippocampus, the aim of this study was to analyze whether changes occur in the expression of prolactin during different stages of life. To determine this, we designed an experimental study in which we analyzed the expression and location of prolactin in the rat hippocampus, Ammon's horn and Dentate Gyrus, during different stages of life (prepubertal, postpubertal, young adult, adult and old) and checked if there are differences related to sex. Overall, the results obtained show that prolactin is present in the rat hippocampus and that prolactin is synthesized, as deduced from the findings obtained via ELISA, immunohistochemistry, qPCR and in situ hybridization. After analyzing the correlation between serum and hippocampal prolactin levels and comparing the amounts of

Indexed as

Dentate GyrusHippocampusProlactinAgingAnimalsFemaleMaleRatsRats, WistarRNA, MessengerProlactinRNA, Messengeragingdentate gyrushippocampus (Ammon’s horn)prolactinsex

Identifiers

PMID40806430
PMCPMC12346806

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.