Evidence map›Paper›PMID 40806359›Full record

ArticleInternational journal of molecular sciences2025

Prognostic Potential of Apoptosis-Related Biomarker Expression in Triple-Negative Breast Cancers.

Miklós Török, Ágnes Nagy, Gábor Cserni, Zsófia Karancsi, Barbara Gregus, Dóra Hanna Nagy, Péter Árkosy, Ilona Kovács, Gabor Méhes, Tibor Krenács

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miklós TörökDepartment of Pathology, University of Debrecen Clinical Center, Kenézy Gyula Campus, 4031 Debrecen, Hungary.
Ágnes NagyDepartment of Pathology and Experimental Medicine, Semmelweis University, 1085 Budapest, Hungary.
Gábor CserniDepartment of Pathology, Bács-Kiskun County Teaching Hospital, 6000 Kecskemet, Hungary.ORCID 0000-0003-1344-7744
Zsófia KarancsiDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-9858-3731
Barbara GregusDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, 1085 Budapest, Hungary.
Dóra Hanna NagyDepartment of Pathology and Experimental Medicine, Semmelweis University, 1085 Budapest, Hungary.
Péter ÁrkosyDepartment of Oncology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Ilona KovácsDepartment of Pathology, University of Debrecen Clinical Center, Kenézy Gyula Campus, 4031 Debrecen, Hungary.
Gabor MéhesDepartment of Pathology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Tibor KrenácsDepartment of Pathology and Experimental Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-9164-065X

Funding

This research was partly funded by a grant from the Hungarian Society of Senology. HSS-2022-5
6 · The paper itself

Abstract

Of breast cancers, the triple-negative subtype (TNBC) is characterized by aggressive behavior, poor prognosis and limited treatment options due to its high molecular heterogeneity. Since insufficient programmed cell death response is a major hallmark of cancer, here we searched for apoptosis-related biomarkers of prognostic potential in TNBC. The expression of the pro-apoptotic caspase 8, cytochrome c, caspase 3, the anti-apoptotic BCL2 and the caspase-independent mediator, apoptosis-inducing factor-1 (AIF1; gene

Indexed as

ApoptosisBiomarkers, TumorTriple Negative Breast NeoplasmsApoptosis Inducing FactorCaspase 3FemaleGene Expression Regulation, NeoplasticHumansMiddle AgedPrognosisProto-Oncogene Proteins c-bcl-2AIFM1 protein, humanApoptosis Inducing FactorBCL2 protein, humanBiomarkers, TumorCaspase 3Proto-Oncogene Proteins c-bcl-2apoptosis inducing factor-1apoptosis pathwayscaspase-3disease prognosistriple-negative breast cancer

Identifiers

PMID40806359
PMCPMC12346514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.