Evidence map›Paper›PMID 40806346›Full record

ArticleInternational journal of molecular sciences2025

Clinical Relevance of

Nemanja Ivkovic, Debora Misic, Ruzica Kozomara, Sasa Jovic, Ahmad Sami, Gordana Velikic, Srboljub Stosic, Gordana Supic

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nemanja IvkovicInstitute for Medical Research, Military Medical Academy, 11040 Belgrade, Serbia.ORCID 0000-0001-8982-8848
Debora MisicInstitute for Medical Research, Military Medical Academy, 11040 Belgrade, Serbia.ORCID 0000-0001-6610-4812
Ruzica KozomaraMedical Faculty of Military Medical Academy, University of Defense, 11000 Belgrade, Serbia.
Sasa JovicMedical Faculty of Military Medical Academy, University of Defense, 11000 Belgrade, Serbia.ORCID 0000-0003-1543-842X
Ahmad SamiCellular and Molecular Radiation Oncology Laboratory, Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-8178-3742
Gordana VelikicHajim School of Engineering, University of Rochester, Rochester, NY 14627, USA.ORCID 0000-0001-6870-0079
Srboljub StosicMedical Faculty of Military Medical Academy, University of Defense, 11000 Belgrade, Serbia.
Gordana SupicInstitute for Medical Research, Military Medical Academy, 11040 Belgrade, Serbia.ORCID 0000-0003-0350-4733

Funding

Medical Faculty of Military Medical Academy, University of Defense, Belgrade, Serbia MFVMA/03/23-25
6 · The paper itself

Abstract

PD-L1, PD-1, FOXP3, and miR-155 are emerging as key modulators of immune evasion and progression of oral squamous cell carcinoma (OSCC). This study investigated the clinical relevance of their gene expression and variants in HPV-negative OSCC. Bulk-tissue mRNA expression was evaluated in 70 patients, while variants in

Indexed as

B7-H1 AntigenCarcinoma, Squamous CellForkhead Transcription FactorsMicroRNAsMouth NeoplasmsProgrammed Cell Death 1 ReceptorAdultAgedBiomarkers, TumorClinical RelevanceFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPolymorphism, Single NucleotideB7-H1 AntigenBiomarkers, TumorCD274 protein, humanForkhead Transcription FactorsFOXP3 protein, humanMicroRNAsMIRN155 microRNA, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorFOXP3gene expressiongenetic variantsmiR-155oral cancerOSCCPD-1PD-L1recurrencesurvival

Identifiers

PMID40806346
PMCPMC12347458

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.