Evidence map›Paper›PMID 40806315›Full record

ArticleInternational journal of molecular sciences2025

Extracellular Vesicles-Induced Cell Homing and Odontogenesis via microRNA Signaling for Dentin Regeneration.

Venkateswaran Ganesh, Douglas C Fredericks, Emily B Petersen, Henry L Keen, Rui He, Jordon D Turner, James A Martin, Aliasger K Salem, Kyungsup Shin, Abhishek Parolia and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Venkateswaran GaneshDepartment of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-2776-7431
Douglas C FredericksDepartment of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-3275-9508
Emily B PetersenDepartment of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Henry L KeenIowa Institute of Human Genetics, University of Iowa, Iowa City, IA 52242, USA.ORCID 0009-0008-3548-7839
Rui HePharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.
Jordon D TurnerDepartment of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
James A MartinDepartment of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Aliasger K SalemPharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-1923-6633
Kyungsup ShinDepartment of Orthodontics, College of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA 52242, USA.
Abhishek ParoliaDepartment of Endodontics, College of Dentistry and Dental Clinics, University of Iowa, Iowa City, IA 52242, USA.
Dongrim SeolDepartment of Orthopedics and Rehabilitation, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-0383-3756

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Exosome-based Cell Homing and Lineage-Specific Differentiation Strategies for Dental Pulp RegenerationR03DE030515 · NIDCR · UNIVERSITY OF IOWA · PI SEOL, DONG RIM · 2021 to 2022
$303k
NIDCR NIH HHS R03 DE030515NIDCR NIH HHS R03DE030515NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Reparative tertiary dentinogenesis requires the recruitment and odontogenic differentiation of dental pulp stem cells (DPSCs). Extracellular vesicles (EVs) as bioactive molecules have gained attention in regenerative medicine for their ability to mediate tissue repair through intercellular communication, influencing cell recruitment, proliferation, and differentiation. This study aimed to evaluate the effects of EVs on DPSC homing and odontogenic differentiation for dentin regeneration. DPSC-derived EVs were cultured in either growth (EV-G) or odontogenic differentiation (EV-O) conditions and isolated using a modified precipitation method. EVs were characterized by nanoparticle tracking analysis, scanning electron microscopy, antibody array, and cellular uptake assay. Treatment with 5 × 10

Indexed as

DentinExtracellular VesiclesMicroRNAsOdontogenesisRegenerationAnimalsCell DifferentiationCell MovementDental PulpGene Expression RegulationPrimary Cell CulturePulpotomyRabbitsRegenerative EndodonticsStem CellsMicroRNAscell homingdental pulp stem cellsdentinogenesisdentin regenerationextracellular vesiclesmicroRNAodontogenesis

Identifiers

PMID40806315
PMCPMC12346742

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.