Evidence map›Paper›PMID 40806307›Full record

ArticleInternational journal of molecular sciences2025

Topical MTH1 Inhibition Suppresses SKP2-WNT5a-Driven Psoriatic Hyperproliferation.

Cecilia Bivik Eding, Ines Köhler, Lavanya Moparthi, Florence Sjögren, Blanka Andersson, Debojyoti Das, Deepti Verma, Martin Scobie, Ulrika Warpman Berglund, Charlotta Enerbäck

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cecilia Bivik EdingIngrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.ORCID 0000-0003-2769-0016
Ines KöhlerIngrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.ORCID 0000-0002-9260-8528
Lavanya MoparthiIngrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.ORCID 0000-0002-6030-3084
Florence SjögrenIngrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.
Blanka AnderssonIngrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.ORCID 0000-0002-9562-0872
Debojyoti DasIngrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.ORCID 0000-0001-6811-3333
Deepti VermaIngrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.
Martin ScobieOxcia AB, 113 34 Stockholm, Sweden.
Ulrika Warpman BerglundOxcia AB, 113 34 Stockholm, Sweden.
Charlotta EnerbäckIngrid Asp Psoriasis Research Center, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.ORCID 0000-0003-1769-3790

Funding

ALF Grants, Region Östergötland n/aIngrid Asp Foundation n/athe Swedish Psoriasis Association n/athe Welander Foundation n/a
6 · The paper itself

Abstract

Topically applied TH1579 alleviated the psoriatic phenotype in the imiquimod-induced psoriasis mouse model by decreasing CD45

Indexed as

DNA Repair EnzymesPhosphoric Monoester HydrolasesPsoriasisS-Phase Kinase-Associated ProteinsWnt-5a ProteinAdministration, TopicalAnimalsCell ProliferationDisease Models, AnimalHumansImiquimodKeratinocytesMiceSkinDNA Repair EnzymesImiquimodPhosphoric Monoester HydrolasesS-Phase Kinase-Associated ProteinsWnt-5a ProteinWnt5a protein, mouseinflammationkeratinocytesMTH1proliferationpsoriasisskin

Identifiers

PMID40806307
PMCPMC12346197

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.