Evidence map›Paper›PMID 40806272›Full record

ArticleInternational journal of molecular sciences2025

Electrochemical Nanostructured Aptasensor for Direct Detection of Glycated Hemoglobin.

Luminita Fritea, Cosmin-Mihai Cotrut, Iulian Antoniac, Simona Daniela Cavalu, Luciana Dobjanschi, Angela Antonescu, Liviu Moldovan, Maria Domuta, Florin Banica

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luminita FriteaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania.
Cosmin-Mihai CotrutFaculty of Material Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, Romania.ORCID 0000-0002-8991-7485
Iulian AntoniacFaculty of Material Science and Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, Romania.ORCID 0000-0003-0112-3494
Simona Daniela CavaluFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania.ORCID 0000-0001-7810-8925
Luciana DobjanschiFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania.
Angela AntonescuFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania.ORCID 0000-0002-0427-4717
Liviu MoldovanFaculty of Electrical Engineering and Information Technology, University of Oradea, 1 Universitatii Street, 410087 Oradea, Romania.
Maria DomutaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania.
Florin BanicaFaculty of Medicine and Pharmacy, University of Oradea, 10 P-ta 1 December Street, 410073 Oradea, Romania.

Funding

University of Oradea 247/2022University of Oradea 324/2021
6 · The paper itself

Abstract

Glycated hemoglobin (HbA1c) is an important biomarker applied for the diagnosis, evaluation, and management of diabetes; therefore, its accurate determination is crucial. In this study, an innovative nanoplatform was developed, integrating carbon nanotubes (CNTs) with enhanced hydrophilicity achieved through cyclodextrin (CD) functionalization, and combined with gold nanoparticles (AuNPs) electrochemically deposited onto a screen-printed carbon electrode. The nanomaterials significantly improved the analytical performance of the sensor due to their increased surface area and high electrical conductivity. This nanoplatform was employed as a substrate for the covalent attachment of thiolated ferrocene-labeled HbA1c specific aptamer through Au-S binding. The electrochemical signal of ferrocene was covered by a stronger oxidation peak of Fe

Indexed as

Aptamers, NucleotideBiosensing TechniquesElectrochemical TechniquesGlycated HemoglobinNanostructuresElectrodesFerrous CompoundsGoldHumansLimit of DetectionMetallocenesMetal NanoparticlesNanotubes, CarbonAptamers, NucleotideferroceneFerrous CompoundsGlycated HemoglobinGoldhemoglobin A1c protein, humanMetallocenesNanotubes, Carbonaptamercarbon nanotubeselectrochemical sensorglycated hemoglobingold nanoparticlesscreen-printed carbon electrode

Identifiers

PMID40806272
PMCPMC12345722

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.