Evidence map›Paper›PMID 40806263›Full record

ArticleInternational journal of molecular sciences2025

Role of Dystrophic Calcification in Reparative Dentinogenesis After Rat Molar Pulpotomy.

Naoki Edanami, Kunihiko Yoshiba, Razi Saifullah Ibn Belal, Nagako Yoshiba, Shoji Takenaka, Naoto Ohkura, Shintaro Takahara, Takako Ida, Rosa Baldeon, Susan Kasimoto and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Naoki EdanamiDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.ORCID 0000-0001-7644-8360
Kunihiko YoshibaDivision of Oral Science for Health Promotion, Department of Oral Health and Welfare, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.
Razi Saifullah Ibn BelalDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.ORCID 0000-0002-5672-9402
Nagako YoshibaDivision of Oral Science for Health Promotion, Department of Oral Health and Welfare, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.
Shoji TakenakaDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.
Naoto OhkuraDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.ORCID 0000-0003-3807-2328
Shintaro TakaharaDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.
Takako IdaDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.ORCID 0000-0001-9299-5903
Rosa BaldeonDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.
Susan KasimotoDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.ORCID 0000-0002-9796-0483
Pemika ThongtadeDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.
Yuichiro NoiriDivision of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8126, Japan.ORCID 0000-0001-6030-6552

Funding

Japan Society for the Promotion of Science 21K16966Japan Society for the Promotion of Science 23K09164 to N.E
6 · The paper itself

Abstract

Vital pulp therapy with calcium hydroxide or mineral trioxide aggregate (MTA) rapidly induces dystrophic calcification and promotes the accumulation of two members of small integrin-binding ligand N-linked glycoproteins: osteopontin (OPN) and dentin matrix protein-1 (DMP1). However, the precise relationship between these initial events and their roles in reparative dentinogenesis remain unclear. This study aimed to clarify the relationship between dystrophic calcification, OPN and DMP1 accumulation, and reparative dentin formation. Pulpotomy was performed on rat molars using MTA or zirconium oxide (ZrO

Indexed as

DentinogenesisMolarPulpotomyAluminum CompoundsAnimalsCalcium CompoundsDental PulpDrug CombinationsExtracellular Matrix ProteinsMaleOsteopontinOxidesPhosphoproteinsRatsRats, Sprague-DawleySilicatesAluminum CompoundsCalcium CompoundsDmp1 protein, ratDrug CombinationsExtracellular Matrix Proteinsmineral trioxide aggregateOsteopontinOxidesPhosphoproteinsSilicatesZirconiumzirconium oxidedentin matrix protein-1dystrophic calcificationosteopontinpulpotomyreparative dentinogenesis

Identifiers

PMID40806263
PMCPMC12346537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.