Evidence map›Paper›PMID 40806255›Full record

ArticleInternational journal of molecular sciences2025

Electromagnetic Transduction Therapy (EMTT) Enhances Tenocyte Regenerative Potential: Evidence for Senolytic-like Effects and Matrix Remodeling.

Matteo Mancini, Mario Vetrano, Alice Traversa, Carlo Cauli, Simona Ceccarelli, Florence Malisan, Maria Chiara Vulpiani, Nicola Maffulli, Cinzia Marchese, Vincenzo Visco and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matteo ManciniTrinity Centre for Biomedical Engineering, Trinity College, D02 R590 Dublin, Ireland.
Mario VetranoDepartment of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-8680-4004
Alice TraversaDepartment of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy.ORCID 0000-0001-6138-6179
Carlo CauliDepartment of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Simona CeccarelliDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-8789-7719
Florence MalisanDepartment of Biomedicine and Prevention, Laboratory of Signal Transduction, Tor Vergata University of Rome, 00133 Rome, Italy.ORCID 0000-0002-0213-9407
Maria Chiara VulpianiDepartment of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.
Nicola MaffulliDepartment of Medical-Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-5327-3702
Cinzia MarcheseDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-9280-8917
Vincenzo ViscoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0001-5067-3121
Danilo RanieriDepartment of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy.ORCID 0000-0001-5039-0834

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendinopathies are a significant challenge in musculoskeletal medicine, with current treatments showing variable efficacy. Electromagnetic transduction therapy (EMTT) has emerged as a promising therapeutic approach, but its biological effects on tendon cells remain largely unexplored. Here, we investigated the effects of EMTT on primary cultured human tenocytes' behavior and functions in vitro, focusing on cellular responses, senescence-related pathways, and molecular mechanisms. Primary cultures of human tenocytes were established from semitendinosus tendon biopsies of patients undergoing anterior cruciate ligament (ACL) reconstruction (

Indexed as

Extracellular MatrixMagnetic Field TherapyRegenerationTenocytesAdolescentAdultCell MovementCell ProliferationCells, CulturedCell SurvivalCellular SenescenceHumansMaleYoung Adultcell migrationEMTTextracellular matrix remodelinghuman tenocytesmechanotransductionsenescencesenolytictendinopathytendon regeneration

Identifiers

PMID40806255
PMCPMC12346084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.