Evidence map›Paper›PMID 40806252›Full record

ArticleInternational journal of molecular sciences2025

Growth Hormone Signaling in Bladder Cancer: Transcriptomic Profiling of Patient Samples and In Vitro Evidence of Therapy Resistance via ABC Transporters and EMT Activation.

Emily Davis, Lydia J Caggiano, Hannah Munholland, Reetobrata Basu, Darlene E Berryman, John J Kopchick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily DavisInstitute for Molecular Medicine and Aging, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Lydia J CaggianoInstitute for Molecular Medicine and Aging, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Hannah MunhollandInstitute for Molecular Medicine and Aging, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Reetobrata BasuInstitute for Molecular Medicine and Aging, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.ORCID 0000-0001-8415-1356
Darlene E BerrymanInstitute for Molecular Medicine and Aging, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.ORCID 0000-0003-4240-9229
John J KopchickInstitute for Molecular Medicine and Aging, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth hormone (GH) signaling has been implicated in tumor progression and therapy resistance across multiple cancer types, yet its role in bladder cancer remains largely unexplored. In this study, we investigated the impact of GH and its receptor (GHR) on therapy resistance and disease progression in urothelial carcinoma (UC) through integrated transcriptomic and in vitro analyses. Transcriptomic profiling of The Cancer Genome Atlas bladder cancer cohort revealed that high tumoral

Indexed as

ATP-Binding Cassette TransportersDrug Resistance, NeoplasmEpithelial-Mesenchymal TransitionHuman Growth HormoneSignal TransductionTranscriptomeUrinary Bladder NeoplasmsCell Line, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleReceptors, SomatotropinATP-Binding Cassette TransportersHuman Growth HormoneReceptors, Somatotropinbladder cancergrowth hormonegrowth hormone receptorTCGAtherapy resistance

Identifiers

PMID40806252
PMCPMC12345844

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.