Evidence map›Paper›PMID 40806206›Full record

ArticleInternational journal of molecular sciences2025

Prognostic Implications of T Cell Receptor Repertoire Diversity in Cervical Lymph Nodes of Oral Squamous Cell Carcinoma Patients.

Kenichi Kumagai, Yoshiki Hamada, Akihisa Horie, Yudai Shimizu, Yoshihiro Ohashi, Reo Aoki, Taiki Suzuki, Koji Kawaguchi, Akihiro Kuroda, Takahiro Tsujikawa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kenichi KumagaiDepartment of Oral-Maxillofacial Surgery and Orthodontics, The University of Tokyo Hospital, Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Yoshiki HamadaDepartment of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Akihisa HorieDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Kawasaki 211-8510, Japan.
Yudai ShimizuDepartment of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Yoshihiro OhashiDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Kawasaki 211-8510, Japan.
Reo AokiDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Kawasaki 211-8510, Japan.
Taiki SuzukiDepartment of Oral and Maxillofacial Surgery, Kanto Rosai Hospital, 1-1 Kizukisumiyoshicho, Kawasaki 211-8510, Japan.ORCID 0000-0003-2000-1660
Koji KawaguchiDepartment of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Akihiro KurodaDepartment of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Takahiro TsujikawaDepartment of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, 465 Kajiicho, Kamigyo-ku, Kyoto 602-8566, Japan.ORCID 0000-0003-1647-342X
Kazuto HoshiDepartment of Oral-Maxillofacial Surgery and Orthodontics, The University of Tokyo Hospital, Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Kazuhiro KakimiDepartment of Immunology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.ORCID 0000-0003-2631-3040

Funding

Japan Society for the Promotion of Science 22K10113Japan Society for the Promotion of Science 23K09385
6 · The paper itself

Abstract

The immune landscape of tumor-draining lymph nodes (TDLNs) plays a critical role in shaping antitumor responses and influencing prognosis in oral squamous cell carcinoma (OSCC). Among patients with lymph node (LN) metastasis, clinical outcomes vary widely, yet reliable biomarkers for prognostic stratification remain limited. This study aimed to identify immune features in tumors and LNs that differentiate between favorable and poor outcomes in OSCC patients with nodal metastasis. We analyzed T cell receptor (TCR) CDR3 repertoires and the expression of immune-related genes in primary tumors and paired sentinel LNs from OSCC patients who underwent tumor resection and lymphadenectomy. Patients were divided into three groups: Group A (no nodal metastasis), Group B1 (metastasis without recurrence), and Group B2 (metastasis with recurrence). TCR diversity was assessed using the Shannon index. The expression of immune-related genes (e.g.,

Indexed as

Carcinoma, Squamous CellLymph NodesMouth NeoplasmsReceptors, Antigen, T-CellAdultAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMaleMiddle AgedPrognosisBiomarkers, TumorReceptors, Antigen, T-Celllymph node metastasisoral squamous cell carcinoma (OSCC)prognostic biomarkerrisk stratificationShannon diversity indexT cell receptor (TCR) repertoiretumor-draining lymph node (TDLN)

Identifiers

PMID40806206
PMCPMC12346881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.