Evidence map›Paper›PMID 40806205›Full record

ArticleInternational journal of molecular sciences2025

Zyxin Gene Expression in Patients with Varying Degrees of Coronary Artery Disease.

Joanna Głogowska-Ligus, Józefa Dąbek, Agata Wypych-Ślusarska, Klaudia Oleksiuk, Karolina Krupa-Kotara, Ewelina Sobecko, Elżbieta Czech, Jerzy Słowiński

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joanna Głogowska-LigusDepartment of Epidemiology, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Józefa DąbekDepartment of Cardiology, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0002-8257-6614
Agata Wypych-ŚlusarskaDepartment of Epidemiology, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0002-3741-574X
Klaudia OleksiukDepartment of Epidemiology, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0001-6948-9084
Karolina Krupa-KotaraDepartment of Epidemiology, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0001-9330-0771
Ewelina SobeckoDepartment of Biostatistics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Elżbieta CzechDepartment of Biostatistics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Jerzy SłowińskiDepartment of Epidemiology, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.ORCID 0000-0003-2470-2296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute coronary syndrome (ACS) remains the leading cause of mortality in developed countries. Although recent advances have improved our understanding of the pathophysiology of ACS and its primary consequence, myocardial infarction, many questions remain regarding the molecular and cellular changes occurring during and after an infarction. This study aimed to evaluate the expression levels of the zyxin (ZYX) gene in patients with ACS, stable coronary artery disease (stable CAD), and healthy controls. RNA was extracted from PBMCs and analyzed by quantitative real-time PCR (qRT-PCR). Gene expression was measured using TaqMan Gene Expression Assays and the number of ZYX mRNA molecules was quantified based on qRT-PCR kinetics. Kruskal-Wallis was used to compare gene expression levels among the three groups. A significantly higher number of ZYX gene copies was observed in both the ACS and stable CAD groups than in healthy controls (

Indexed as

Acute Coronary SyndromeCoronary Artery DiseaseZyxinAgedCase-Control StudiesFemaleGene Expression RegulationHumansMaleMiddle AgedRNA, MessengerRNA, MessengerZyxinZYX protein, humanacute coronary syndromestable coronary artery diseasezyxin

Identifiers

PMID40806205
PMCPMC12346200

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.