Evidence map›Paper›PMID 40806195›Full record

ArticleInternational journal of molecular sciences2025

Structural Features and In Vitro Antiviral Activities of Fungal Metabolites Sphaeropsidins A and B Against Bovine Coronavirus.

Luca Del Sorbo, Maria Michela Salvatore, Clementina Acconcia, Rosa Giugliano, Giovanna Fusco, Massimiliano Galdiero, Violetta Iris Vasinioti, Maria Stella Lucente, Paolo Capozza, Annamaria Pratelli and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luca Del SorboDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.
Maria Michela SalvatoreDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0001-8318-3065
Clementina AcconciaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy.
Rosa GiuglianoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0001-9923-3194
Giovanna FuscoIstituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, Italy.ORCID 0000-0003-3139-7672
Massimiliano GaldieroDepartment of Experimental Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.ORCID 0000-0002-1576-6290
Violetta Iris VasiniotiDepartment of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy.ORCID 0000-0002-3798-0407
Maria Stella LucenteDepartment of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy.
Paolo CapozzaDepartment of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy.ORCID 0000-0001-5563-1131
Annamaria PratelliDepartment of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy.ORCID 0000-0001-6862-1792
Luigi RussoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy.ORCID 0000-0002-1577-176X
Rosa IacovinoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy.ORCID 0000-0001-7792-9342
Anna AndolfiDepartment of Chemical Science, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0001-8949-3654
Filomena FioritoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0002-6658-7807

Funding

European Union-Next Generation EU Project PRIN Prot. 2022WTWB9R "Antiviral activity of drugs and natural compounds evaluated in vitro and in vivo against bovine coronavirus: a translational study to SARS-CoV-2"Istituto Zooprofilattico Sperimentale del Mezzogiorno IZS ME 03-22 RC "Coronavirosi nei ruminanti domestici nel sud Italia: descrizione di casi di in-fezioni zoonotiche inverse"
6 · The paper itself

Abstract

The scientific community's interest in natural compounds with antiviral properties has considerably increased after the emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV-2), especially for their potential use in the treatment of the COVID-19 infection. From this perspective, bovine coronavirus (BCoV), member of the genus β-CoV, represents a valuable virus model to study human β-CoVs, bypassing the risks of handling highly pathogenic and contagious viruses. Pimarane diterpenes are a significant group of secondary metabolites produced by phytopathogenic fungi, including several

Indexed as

Antiviral AgentsCoronavirus, BovineDiterpenesFungiAnimalsCattleCell LineCell SurvivalHumansMolecular Docking SimulationSpike Glycoprotein, CoronavirusAntiviral AgentsDiterpenesSpike Glycoprotein, Coronavirusantiviral secondary metabolitesaryl hydrocarbon receptorbovine coronavirus

Identifiers

PMID40806195
PMCPMC12346457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.