Evidence map›Paper›PMID 40806193›Full record

ArticleInternational journal of molecular sciences2025

Design, Synthesis, and Anticancer Evaluation of New Small-Molecule EGFR Inhibitors Targeting NSCLC and Breast Cancer.

Belgin Sever, Masami Otsuka, Mikako Fujita, Halilibrahim Ciftci

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Belgin SeverDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Türkiye.ORCID 0000-0003-4847-9711
Masami OtsukaMedicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Mikako FujitaMedicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.ORCID 0000-0001-6705-4052
Halilibrahim CiftciMedicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.ORCID 0000-0002-9796-7669

Funding

Scientific and Technological Research Council of Turkey (TUBITAK) 122Z775
6 · The paper itself

Abstract

EGFR is the most frequently altered driver gene in non-small-cell lung cancer (NSCLC), and its overexpression is also associated with breast cancer. In the present study, we synthesized 18 new compounds (

Indexed as

Antineoplastic AgentsBreast NeoplasmsCarcinoma, Non-Small-Cell LungLung NeoplasmsProtein Kinase InhibitorsSmall Molecule LibrariesA549 CellsApoptosisCell Line, TumorCell ProliferationDrug DesignErbB ReceptorsFemaleHumansJurkat CellsMCF-7 CellsAntineoplastic AgentsEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsSmall Molecule Librariesapoptosisbreast cancerchalconecytotoxicityEGFRin silico studiesNSCLCpyrazolinesmall-molecule inhibitorsthiazole

Identifiers

PMID40806193
PMCPMC12346557

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.